微泡超声空化在增强微波消融对肝脏肿瘤的热消融效应中的价值  

Valuable study of microbubble ultrasound cavitation enhanced microwave ablation for liver cancer

作　　者：胡志文[1,2] 萧淑宜 格桑卓玛[2] 金海 董燕 柳建华[1] HU Zhiwen;XIAO Shuyi;GESANG Zhuoma;JIN Hai;DONG Yan;LIU Jianhua(Department of Medical Ultrasound,Guangzhou First People's Hospital,Guangzhou 510180,China;Function Department,Linzhi People's Hospital,Linzhi 860000,China)

机构地区：[1]广州市第一人民医院超声医学科,广州510180 [2]林芝市人民医院功能科,林芝860000

出　　处：《广州医药》2021年第1期43-48,共6页Guangzhou Medical Journal

摘　　要：目的通过研究微泡超声空化增强微波消融对兔VX2肿瘤的热消融效应来探究其在肿瘤治疗中的价值。方法24只肝脏移植瘤兔随机分为空白对照组、单纯超声空化治疗组、单纯微波消融治疗组、超声空化联合微波消融治疗组4组。利用增强超声显示每组治疗前后肿瘤的大小、形状和轮廓并通过温度针来检测治疗区域的局部温度。结果联合治疗组血流灌注缺损最严重,微波消融组和联合治疗组缺损体积分别为1.53±0.20和1.68±0.43(P=0.117);微波消融组以及联合治疗组消融治疗时温度达平台时间分别为(21.7±5.0)s和(10.3±5.0)s(P<0.01),最高温度(℃)分别为100.9±5.0和134.1±6.0(P<0.01)。结论MWA联合MEUS治疗肝癌可使治疗区局部温度急剧升高至峰值温度,有望提高肝癌治疗效果。Objective To investigate the thermal ablation effect of microbubble ultrasound cavitation combined with microwave ablation on rabbit VX2 tumors.Methods Twenty-four rabbits with liver transplantation tumors were randomly divided into four groups:blank control group,ultrasound-only cavitation treatment group,microwave-only ablation treatment group,and ultrasound-cavitation combined with microwave ablation treatment group.Enhanced ultrasound was used to show the size,shape and contour of the tumor before and after treatment in each group,and the local temperature of the treatment area was detected by a temperature needle.Results The blood flow perfusion defect was the most severe in the combined treatment group.The defect volume of the microwave ablation group and the combined treatment group were 1.53±0.20 and 1.68±0.43(P=0.117).The temperature reached the plateau time in the microwave ablation group and the combined treatment group.It was(21.7±5.0)s and(10.3±5.0)s(P<0.01),and the highest temperature(℃)was 100.9±5.0 and 134.1±6.0(P<0.01).Conclusion MWA combined with MEUS for liver cancer can sharply increase the local temperature in the treatment area to the peak temperature,which is expected to improve the treatment effect of liver cancer.

关 键 词：微泡超声空化 微波消融 肝癌 治疗 

分 类 号：R735.7[医药卫生—肿瘤]