住院精神分裂症患者高血糖发生率及其相关因素  

Investigation and analysis of the incidence of hyperglycemia and its related factors in hospitalized schizophrenia patients

作　　者：班春霞[1] 李慧娟[1] 陈翔春[1] 孟美玲 张袁杰 于伟霞 郭本玉[1] BAN Chunxia;LI Huijuan;CHEN Xiangchun(Mental Health Center of Jiading District in Shanghai,Shanghai 201806,China)

机构地区：[1]上海市嘉定区精神卫生中心,201806

出　　处：《中国健康心理学杂志》2021年第2期179-183,共5页China Journal of Health Psychology

基　　金：上海市嘉定区农业和社会事业科研项目(编号:JDKW-2019-W06);嘉定区精神卫生重点专科建设项目(编号:JDYXZDZK-3)。

摘　　要：目的:对住院精神分裂症患者高血糖发生率及其相关因素进行调查。方法:采用自制的调查表对287例住院精神分裂症患者进行了调查,分别收集了患者的性别、年龄、受教育年限、病程、精神疾病家族史、既往病史(高血压、高脂血症)、服用抗精神病药物等相关资料,同时测了体质量、身高、血糖、甘油三酯、总胆固醇、高密度脂蛋白及低密度脂蛋白等相关指标。结果:287例住院精神分裂症患者中,存有高血糖65例,发生率为22.6%。住院精神分裂症患者中,高血糖组年龄明显大于非高血糖组(t=-2.310,P<0.05);高血糖组甘油三酯明显高于非高血糖组(t=-2.512,P<0.05);高血糖组高密度脂蛋白明显低于非高血糖组(t=2.687,P<0.01)。≥50岁的住院精神分裂症患者伴有高血糖比率明显高于<50岁的患者(χ^(2)=6.609,P<0.05);≥50岁的住院精神分裂症患者空腹血糖明显高于<50岁的患者(t=-2.978,P<0.01)。Logistic回归分析显示,年龄、家族史、甘油三酯与高血糖的发生有关(P<0.05)。结论:住院精神分裂症患者高血糖发生率较高,年龄越大、有精神疾病家族史、甘油三酯值越高的患者,发生高血糖的风险越大。Objective:To investigate the incidence of hyperglycemia of hospitalized schizophrenia inpatients and relative factors.Methods:A self-made questionnaire was used to investigate the 287hospitalized schizophrenia inpatients.Gender,age,educated years,course of disease,family history of mental illness,past medical history(hypertension,hyperlipidemia),and use of antipsychotic drugs were collected.Meanwhile,body mass,height,blood glucose,triglycerides,total cholesterol,high-density lipoprotein and low-density lipoprotein were measured.Results:Among 287hospitalized schizophrenia inpatients,65(22.6%)cases of which were complicated with hyperglycemia.Among hospitalized schizophrenic patients,the age of hyperglycemia group was significantly higher than that of non-hyperglycemia group(t=-2.310,P<0.05).Triglyceride in the hyperglycemia group was significantly higher than that in the non-hyperglycemia group(t=-2.512,P<0.05).High-density lipoprotein(HDL)in the hyperglycemia group was significantly lower than that in the non-hyperglycemia group(t=2.687,P<0.01).The ratio of hospitalized schizophrenic patients aged≥50years with hyperglycemia was significantly higher than that of patients aged<50 years(χ^(2)=6.609,P<0.05).Fasting blood glucose of hospitalized schizophrenic patients aged≥50years was significantly higher than that of patients aged<50years(t=-2.978,P<0.01).Logistic regression analysis showed that age,family history and triglyceride were associated with the occurrence of hyperglycemia(P<0.05).Conclusion:The incidence of hyperglycemia is higher in hospitalized schizophrenics.Patients with a higher risk of hyperglycemia were older,has a family history of mental illness,and has higher triglyceride levels.

关 键 词：精神分裂症 高血糖 甘油三酯 住院患者 

分 类 号：R749.3[医药卫生—神经病学与精神病学]