丙酮酸盐对重要脏器缺氧性损伤作用的研究进展  

Research progress of pyruvate on hypoxic injury of important organs

作　　者：耿莉莉 周国勇 李娟 刘虎仙 孙可 孙永华[2] 曾丁 Geng Lili;Zhou Guoyong;Li Juan;Liu Huxian;Sun Ke;Sun Yonghua;Zeng Ding(Department of Burns and Plastic Surgery,PLA Rocket Force Characteristic Medical Center, Beijing 100088, China;Department of Burns, Beijing Jishuitan Hospital, Beijing 100035, China)

机构地区：[1]解放军火箭军特色医学中心烧伤整形科,北京100088 [2]北京积水潭医院烧伤科,100035

出　　处：《中华损伤与修复杂志（电子版）》2020年第6期499-501,共3页Chinese Journal of Injury Repair and Wound Healing(Electronic Edition)

摘　　要：丙酮酸盐作为机体糖酵解的中间代谢产物,具有广泛的生物学、药理学及潜在临床应用价值。大量动物研究表明,丙酮酸钠在机体遭受各种原因引起的缺氧性损伤病理生理过程中,均表现出能减轻细胞线粒体损伤、抗炎、抗氧化、抑制细胞凋亡、纠正乳酸性酸中毒等作用,从而保护脑、肾、消化道等重要脏器功能。本文对丙酮酸盐的上述作用及其可能机制进行了简要综述,为丙酮酸盐在各种重大战、创伤的药物复苏应用价值进行了展望。Pyruvate,as an intermediate metabolite of glycolysis,has a wide range of biological,pharmacological and clinical value.A large number of animal studies have shown that sodium pyruvate can reduce mitochondrial damage,anti-inflammatory,anti-oxidation,inhibit cell apoptosis and correct lactic acid acidosis in the pathophysiological process of hypoxic injury caused by various reasons,so as to protect the brain,kidney,digestive tract and other important organ functions.In this paper,the above effects of pyruvate and its possible mechanism were briefly reviewed,and the application value of pyruvate in drug resuscitation of various major wars and trauma was prospected.

关 键 词：丙酮酸盐类 缺氧性损伤 复苏 

分 类 号：R73[医药卫生—肿瘤]