抑癌基因PTEN在乳腺浸润性小叶癌组织中的表达及临床意义  

Expression and clinical significance of PTEN in invasive lobular breast carcinoma

作　　者：何中南 谭敏华 周泳健 马德奎 陆国芬 何颜英 HE Zhong-nan;TAN Min-hua;ZHOU Yong-jian;MA De-kui;LU Guo-fen;HE Yan-ying(Department of Breast Surgery,Guangdong Medical University,Zhaoqing 526000,China;Department of Pathology,Zhaoqing First People's Hospital,Guangdong Medical University,Zhaoqing 526000,China)

机构地区：[1]广东医科大学附属肇庆市第一人民医院乳腺外科,广东肇庆526000 [2]广东医科大学附属肇庆市第一人民医院病理科,广东肇庆526000

出　　处：《广东医科大学学报》2021年第1期44-48,共5页Journal of Guangdong Medical University

摘　　要：目的探讨乳腺浸润性小叶癌组织中PTEN的表达及临床意义。方法免疫组化检测46例乳腺浸润性小叶癌组织、癌旁组织及50例乳腺增生组织中PTEN表达,并分析PTEN表达与临床病理特征的关系。结果PTEN在浸润性小叶癌组织中表达明显低于癌旁组织和乳腺增生组织(P<0.01)。PTEN表达与病理分期、组织学分级、淋巴结转移、脉管癌栓侵犯、Ki-67表达有关(P<0.01或0.05),而与患者年龄、肿瘤直径、雌激素/孕激素受体、表皮生长子受体2水平无关(P>0.05)。结论浸润性小叶癌组织中PTEN表达降低,可能是浸润性小叶癌复发和转移的潜在预测指标。Objective To investigate the expression and clinical significance of PTEN in invasive lobular breast carcinoma(ILBC).Methods PTEN expression was determined by immunohistochemistry in 46 ILBC and paracancerous specimens and 50 breast hyperplasia samples.The relationship between PTEN expression and clinicopathological characteristics was analyzed.Results PTEN expression was significantly lower in ILBC than in paracancerous and breast hyperplasia tissue(P<0.01).PTEN expression in ILBC was correlated with tumor stage,histological grade,lymph node metastasis,vascular cancerous emboli and Ki-67 expression(P<0.01 or 0.05),but not with age,tumor diameter,and expression of estrogen/progesterone receptor and HER2(F>0.05).Conclusion PTEN downexpression might serve as a potential predictor of recurrence and metastasis of ILBC.

关 键 词：PTEN 乳腺浸润性小叶癌 免疫组织化学染色 

分 类 号：R73[医药卫生—肿瘤]