薏苡附子败酱散治疗溃疡性结肠炎疗效的Meta分析  

A Meta-analysis of therapeutic effect of Yiyi Fuzi Baijiang powder on ulcerative colitis

作　　者：李红琳 薛怡 陈江[2] LI Honglin;XUE Yi;CHEN Jiang(Shanghai University of Traditional Chinese Medicine.Shanghai,201203,China;Suzhou Hospital of Traditional Chinese Medicine,Shanghai University of Chinese Medicine,Suzhou.215009,China)

机构地区：[1]上海中医药大学,上海201203 [2]上海中医药大学苏州市中医医院

出　　处：《中国中西医结合消化杂志》2021年第2期132-137,共6页Chinese Journal of Integrated Traditional and Western Medicine on Digestion

基　　金：江苏省中医药管理局项目(No:YB201954);苏州市科技局民生科技基金(医疗卫生应用基础研究项目)(No:sys2018093)。

摘　　要：目的:评价薏苡附子败酱散治疗溃疡性结肠炎(UC)的有效性。方法:通过计算机检索中国知网、维普、万方、PubMed以及Embas等数据库,并辅以手工检索的方法,对关于薏苡附子败酱散治疗UC的随机对照实验研究进行筛选,文献检索时限为自数据库建立至今,对纳入的文献资料采用RevMan5.3进行Meta分析。结果:最终共纳入9篇文献,Meta分析结果显示:附子败酱散治疗UC与西药组比较,总有效率OR=3.25,95%CI:2.15~4.89,Z=5.63(P<0.01);肠黏膜组织学疗效OR=4.98,95%CI:2.55~9.73,Z=4.71(P<0.01);降低炎性因子水平(1)TNF-α:MD=-6.08,95%CI:-7.83~-4.32,Z=6.79(P<0.01),(2)IL-6:MD=-8.18,95%CI:-10.11~-6.25,Z=8.32(P<0.01);不良反应OR=0.58,95%CI:0.10~3.44,Z=0.60(P>0.01)。结论:薏苡附子败酱散单用或联合其他药物治疗UC,临床总有效率、肠黏膜组织疗效以及降低炎性因子TNF-α、IL-6的效果高于对照组,2组不良反应比较,差异无统计学意义。但纳入的文献数量有限,上述研究故仍需要更多高质量的文献数据加以验证。Objective: To evaluate the efficacy of Yiyi Fuzi Baijiang powder in the treatment of ulcerative colitis. Methods: A computer-based search of CNKI,VIP,Wanfang,PubMed and Embase databases was conducted to screen the randomized controlled trials on the treatment of ulcerative colitis with Yiyi Fuzi Baijiang powder.The included literatures were analyzed by revman5.3 software. Results: A total of 9 literatures were included in the meta-analysis.The total effective rate was OR=3.25,95%CI: 2.15-4.89,Z=5.63(P<0.01);the histological efficacy of intestinal mucosa was OR=4.98,95%CI: 2.55-9.73,Z=4.71(P<0.01);the level of inflammatory factors was decreased:(1)TNF-α:MD=-6.08,95%CI:-7.83--4.32,Z=6.79(P<0.01),(2)IL-6:MD=-8.18,95%CI:-10.11--6.25,Z=8.32(P<0.01).The adverse reactions were OR=0.58,95%CI: 0.10-3.44,Z=0.60(P>0.01).Conclusion: Yiyi Fuzi Baijiang powder alone or combined with other drugs in the treatment of ulcerative colitis,the clinical total effective rate,the curative effect of intestinal mucosa tissue and the effect of reducing inflammatory factors TNF-α and IL-6 are higher than those of the control group.The adverse reactions have no statistical difference.However,the number of included literatures is limited,more high-quality literature data are needed to verify our results.

关 键 词：薏苡附子败酱散 溃疡性结肠炎 META分析 

分 类 号：R574.62[医药卫生—消化系统]