C反应蛋白与白蛋白比值在中老年非肌层浸润性膀胱癌患者预后中的意义  

Significance of C-reactive protein and albumin ratio in prognosis of patients with non-myometrial invasion of bladder cancer

作　　者：郭亮[1] 马曜辉 管庆军[1] 马杰锋[1] GUO Liang;MA Yao-hui;GUAN Qing-jun;MA Jie-feng(Department of Urinary Surgery,People's Hospital of Zhengzhou,Zhengzhou 450000,China)

机构地区：[1]郑州人民医院泌尿外科,郑州450000

出　　处：《医药论坛杂志》2021年第2期47-50,共4页Journal of Medical Forum

摘　　要：目的分析C反应蛋白(CRP)与白蛋白(Alb)的比值(CAR)在中老年非肌层浸润性膀胱癌(NMIBC)患者行经尿道膀胱肿瘤切除术(TURBT)预后中的意义。方法收集2015年5月—2016年10月在郑州人民医院行TURBT治疗的NMIBC患者92例;统计患者术前CRP及Alb水平并计算CAR,根据中位值将患者分为高CAR组及低CAR组,比较两组患者临床病理特征及术后恢复指标,Kaplan-Meier法分析两组患者生存期的差异,Cox回归分析影响患者生存期的危险因素。结果高CAR患者和低CAR患者组间肿瘤数量、肿瘤大小、TNM分期、肾积水指标相比差异有统计学意义(P<0.05);低CAR组术后导管留置时间、下床活动时间、住院时间均低于高CAR组(P<0.05);随访截止时,低CAR组存活病例25(54.3%),25(54.3%)例患者复发,高CAR组存活病例20例(43.5%),32(65.2%)例复发,高CAR组的总生存期与低CAR组差异无统计学意义(χ^(2)=2.750,P=0.097),但高CAR组的无进展生存期低于低CAR组(χ^(2)=3.453,P=0.033)。高CAR是影响NMIBC患者术后生存的危险因素[HR(95%CI)=1.653(0.712~3.688),P=0.012]。结论术前高CAR是NMIBC患者预后不良的危险因素,可作为行TURBT的预后参考指标之一。Objective To analyze the significance of the ratio of C-reactive protein(CRP) to albumin(Alb) in the prognosis of(TURBT) in middle-aged and elderly patients with non-myenteric invasive bladder cancer(NMIBC).Methods The collection of 92 cases of NMIBC patients treated by TURBT in People’s Hospital of Zhengzhou.The preoperative CRP and Alb levels were detected and the patients were divided into high CAR group and low CAR group according to the median value of CAR. The clinicopathological features and postoperative recovery indexes of the two groups were compared. Kaplan-Meier method was used to analyze the difference of survival time between the two groups. Cox regression analysis was used to analyze the risk factors affecting the survival time of the patients.Results There were significant differences in tumor number, tumor size, TNM stage and hydronephrosis between patients with high CAR and low CAR(P<0.05). Postoperative catheter indwelling time, out-of-bed activity time and hospital stay time in the low CAR group were all lower than those in the high CAR group(allP<0.05). At the end of follow-up, there were 25(54.3%) surviving cases and 25(54.3%) recurrent cases in the low CAR group, while there were 20(43.5%) surviving cases and 32(65.2%) recurrent cases in the high CAR group. The total survival time between the high CAR group and the low CAR group was not statistically significant(χ^(2)=2.750,P=0.097), but the progression free survival time in the high CAR group was lower than that in the low CAR group(χ^(2)=3.453,P=0.033). High CAR is the risk factor for postoperative survival of NMIBC patients[HR(95%CI)=1.653(0.712~3.688),P=0.012].Conclusion Preoperative high CAR is a risk factor for poor prognosis in patients with NMIBC, which can be used as one of the prognostic reference indexes for TURBT.

关 键 词：C反应蛋白 白蛋白 非肌层浸润性膀胱癌 预后 

分 类 号：R737.14[医药卫生—肿瘤]