水凝胶用于牙髓再生的研究进展  

Research progress on hydrogels for pulp regeneration

作　　者：曹春玲 韩冰[1] 王晓燕[1] Cao Chunling;Han Bing;Wang Xiaoyan(Dept.of Cariology and Endodontics,Peking University School and Hospital of Stomatology&National Clinical Research Center for Oral Diseases&National Engineering Laboratory for Digital and Material Technology of Stomatology&Beijing Key Laboratory of Digital Stomatology,Beijing 100081,China)

机构地区：[1]北京大学口腔医学院·口腔医院牙体牙髓科,国家口腔疾病临床研究中心,口腔数字化医疗技术和材料国家工程实验室,口腔数字医学北京市重点实验室,北京100081

出　　处：《国际口腔医学杂志》2021年第2期192-197,共6页International Journal of Stomatology

基　　金：国家自然科学基金(81771061,81400562)。

摘　　要：水凝胶是一种柔软且生物相容性良好的高分子网络体系,可以作为组织工程研究中的支架材料。牙髓再生是运用组织工程学的原理,将牙髓干细胞在体外培养后植入生物相容性良好且可以被吸收降解的生物支架上,诱导牙髓干细胞形成牙髓-牙本质复合体和类牙髓样组织。水凝胶支架在牙髓再生中发挥着模拟微环境、传递信号分子等重要作用,具有良好的应用前景。本文就不同成分、性质的水凝胶用于牙髓再生的研究进展进行综述。Hydrogel is a soft,biocompatible polymer network system that can be used as a scaffold in tissue engineering.Using the principles of tissue engineering,dental pulp stem cells cultured in vitro can be implanted into biocompatible,degradable scaffolds,and induced to form pulp-dentin complex and dental pulp-like tissue.Hydrogel scaffolds simulate the extracellular microenvironment and transmit signal molecules,representing a promising material for pulp regeneration.This study reviews the applications of hydrogels with different compositions and properties for pulp regeneration.

关 键 词：水凝胶 支架 牙髓再生 组织工程 

分 类 号：R782.2[医药卫生—口腔医学]