磁敏感加权成像在帕金森病诊断及Hoehn-Yahr分级中应用的Meta分析  

The application of susceptibility weighted imaging in the diagnosis of Parkinson's disease and Hoehn-Yahr classification:Meta-analysis

作　　者：唐苏丹 向春红 陈杭 曾健 杨全[1] TANG Sudan;XIANG Chunhong;CHEN Hang;ZENG Jian;YANG Quan(Department of Radiology,Yongchuan Hospital of Chongqing Medical University,Chongqing 402160,China)

机构地区：[1]重庆医科大学附属永川医院放射科,重庆402160

出　　处：《实用放射学杂志》2021年第2期191-195,共5页Journal of Practical Radiology

摘　　要：目的采用Meta分析评价磁敏感加权成像(SWI)在帕金森病(PD)诊断及Hoehn-Yahr分级中的应用。方法检索PubMed、Web of science、Embass、CNKI、万方和维普数据库,搜集关于SWI在PD诊断及Hoehn-Yahr分级中应用的文献。采用RevMan5.3统计软件进行分析。结果共纳入文献13篇。早期PD组与对照组黑质、苍白球相位值总体效应检验[Z=2.39、2.66,P=0.02、0.008,95%CI(-0.05,-0.01)、95%CI(-0.06,-0.01)]差异有统计学意义。中晚期PD组与对照组黑质、苍白球、壳核及尾状核相位值总体效应检验[Z=3.82、2.08、3.75、2.05,P=0.0001、0.04、0.0002、0.04,95%CI(-0.08,-0.03)、95%CI(-0.15,-0.00)、95%CI(-0.09,-0.03)、95%CI(-0.01,-0.00)]差异有统计学意义。中晚期PD组与早期PD组黑质、苍白球相位值总体效应检验[Z=3.64、2.39,P=0.0003、0.02,95%CI(-0.06,-0.02)、95%CI(-0.10,-0.01)]差异有统计学意义。结论早期PD在黑质、苍白球存在异常铁沉积且随着病情进展而增加,SWI对PD的早期诊断及病情评估有重要意义。Objective To evaluate the application of susceptibility weighted imaging(SWI)in the diagnosis of Parkinson's disease(PD)and Hoehn-Yahr classification on Meta-analysis.Methods Literatures about the application of SWI in the diagnosis of PD and Hoehn Yahr classification were searched from PubMed,Web of science,Embass,CNKI,Wanfang and VIP databases.RevMan5.3 software was used for Meta-analysis.Results Totally 13 studies were enrolled.The overall effect value about the phase of substantia nigra and globus pallidus between the early PD group and the control group was statistically significant[Z=2.39,2.66,P=0.02,0.008,95%CI(-0.05,-0.01),95%CI(-0.06,-0.01)].The overall effect value about the phase of substantia nigra,globus pallidus,putamen and caudate nucleus bet wee n the middle and late PD group and the control group was statistically significan[Z=3.82,2.08,3.75,2.05,P=0.0001,0.04,0.0002,0.04,95%CI(-0.08,-0.03),95%CI(-0.15,-0.00),95%CI(-0.09,-0.03),95%CI(-0.01,-0.00)].The overall effect value about the phase of substantia nigra and globus pallidus between the middle and late PD group and the early PD group was statistically significant[Z=3.64,2.39,P=0.0003,0.02,95%CI(-0.06,-0.02),95%CI(-0.10,-0.01)].Conclusion There is abnormal iron deposition in the substa ntia nigra and globus pallidus in early PD,which in crease with the progression of the disease.SWI plays an importa nl role in the early diagnosis and severity assessment of PD.

关 键 词：帕金森病 铁沉积 磁敏感加权成像 META分析 

分 类 号：R742[医药卫生—神经病学与精神病学] R445.2[医药卫生—临床医学]