胃肠道间质瘤的CT特征与病理危险度、免疫组化分型及Hpa蛋白表达的关系  

Relationship between CT characteristics of gastrointestinal stromal tumor and pathological risk,immunohistochemical classification and Hpa protein expression

作　　者：于明川[1] 尚存海[1] 费胜民[1] 刘辉[1] 刘增建 YU Mingchuan;SHANG Cunhai;FEI Shengmin;LIU Hui;LIU Zengjian(Department of Imaging,Shougang Hospital,Peking University,Bejjing 100144,China)

机构地区：[1]北京大学首钢医院影像科,北京100144

出　　处：《实用放射学杂志》2021年第2期252-255,共4页Journal of Practical Radiology

摘　　要：目的研究胃肠道间质瘤(GIST)多层螺旋CT(MSCT)影像特征与其病理危险度、免疫组化分型及乙酚肝素酶(Hpa)蛋白表达的相关性。方法选取75例GIST患者,均行MSCT扫描。根据病理危险度分为低、中、高危组,根据免疫组化分型分为Ⅰ型、Ⅱ型、Ⅲ型、Ⅳ型,采用免疫组化法检测Hpa蛋白表达水平。比较各组间影像特征、Hpa蛋白表达水平,并采用Pearson法分析影像特征与病理危险度、免疫组化分型以及Hpa蛋白表达水平的相关性。结果高危组的肿瘤恶性、密度不均匀、Hpa阳性发生率明显高于低危组(P<0.05)。Ⅰ型患者的肿瘤恶性、密度不均匀、Hpa阳性、CT强化程度轻度发生率明显高于Ⅳ型患者(P<0.05)。Hpa阳性患者的肿瘤恶性、密度不均匀发生率明显高于Hpa阴性患者(P<0.05)。Pearson相关性分析显示病理危险度、免疫组化分型、Hpa表达与肿瘤良恶性、肿瘤密度有显著相关性(P<0.05)。结论GIST的CT表现呈密度不均匀或肿瘤恶性,则可能处于高危病理状态、Ⅰ型免疫组化分型以及Hpa蛋白表达阳性。Objective To study the correlation between the multi spiral computed tomography(MSCT)features and the pathological risk,immunohistochemical classification and heparanase(Hpa)protein expression of gastrointestinal stromal tumor(GIST).Methods A total of 75 patients with GIST who were admitted were all selected for MSCT scanning.They were divided into low,medium and high risk groups according to the pathological risk。and also divided into tvpe Ⅰ,type Ⅱ,type Ⅲ and type Ⅳ according to the immunohistochemical classification.'The expression level of Hpa protein was detected by immunohistochemistry method.The image characteristics and the expression level of Hpa protein were compared among dfflerent groups,and the Pearson correlation was used to analyzxe the relationship betwee the imaging characteristics and the pathological risk,immunohistochemical classification and Hpa protein expression levels.Results The incidences of tumor malignancy,uneven density and positive Hpa expression in high-risk group were significantly higher than those in low-risk group(P<0.05).The incidences of tumor malignancy,uneven density,positive HPa expression and mild degree of CT enhancerment in tvpe Ⅰ patients were significantly higher than those in type Ⅳ patients(P<0.05).The incidence of tumor malignancy and umeven density of Hpa positive patients were significantly higher than those of Hpa negative patients(P<0.05).Pearson correlation analysis showed that the pathological risk,immunohistochemical classification,and Hpa expression were significantly correlated with the tumor benign and malignant and density(P<0.05).Conclusion GIST patients with heterogeneous density on CT or malignant performance may be in high-risk pathological state,type Ⅰimmunohistochemical classification and positive expression of Hpa protein.

关 键 词：胃肠道间质瘤 病理危险度 免疫组化分型 乙酚肝素酶 

分 类 号：R735[医药卫生—肿瘤] R814.42[医药卫生—临床医学]