前列腺特异性抗原密度在PI-RADS v2评分3分患者中的应用价值  

Application value of prostate specific antigen density in the lesion with category 3 of PI-RADS v2

作　　者：吴静[1] 汪贤云 田晓燕 李晓舒[1] 王啸[1] WU Jing;WANG Xianyun;TIAN Xiaoyan;LI Xiaoshu;WANG Xiao(Department of Radiology,the First Affiliated Hospital of Anhui Medical University,Hefei 230022,China)

机构地区：[1]安徽医科大学第一附属医院放射科,安徽合肥230022

出　　处：《实用放射学杂志》2021年第2期271-274,共4页Journal of Practical Radiology

摘　　要：目的探讨前列腺特异性抗原密度(PSAD)在第二版前列腺影像报告和数据系统(PI-RADS v2)评分3分患者中的应用价值。方法回顾性分析接受前列腺穿刺活检且PI-RADS v2评分3分的96例患者。根据病理证实结果分为前列腺癌(PCa)组(20例)和非癌组(76例)。对2组患者的年龄、总前列腺特异性抗原(TPSA)、前列腺体积及PSAD进行正态性检验,采用独立样本t检验(正态分布)或秩和检验(偏态分布)比较2组参数的差异;绘制受试者工作特征(ROC)曲线评估PSAD诊断PI-RADS v2评分3分患者前列腺病灶良恶性的效能,计算最佳诊断阈值。结果2组患者在年龄、前列腺体积和PSAD中差异均有统计学意义(P<0.05),在PSA中差异无统计学意义(P>0.05)。PSAD的曲线下面积(AUC)值为0.827,当阈值取0.205 ng/(mL·cm^(3))时,PSAD诊断PI-RADS v2评分3分患者PCa与非癌的敏感度和特异度分别为75%、81.6%。结论PSAD能有效提高PI-RADS v2评分3分患者中PCa的检出率,对PI-RADS v2评分3分的患者是否需要穿刺提供依据。Objctive To investigate the application value of prostate specifie antigen density(PSAD)in the lesion with category 3 of prostate imanging reporting and data systerm version 2(PI-RADS v2).Methods A retrospective analysis of 96 patients who underwent a prostate biopsy and were assessed as category 3 with a PI-RADS v2.Enrolled patients were divided into prostate cancer(PCa)group(20 cases)and non-cancer group(76 cases)according to the pa thologically confirmed results.The age,total prostate specific antigen(TPSA).prostate volume and PSAD dates of the two groups of patients were all analyzed by the normality test,and the differences in the parameters between the two groups were compared by using the independent-sample t test(normal distribution)and the rank sum test(skewed distribution).Receiver operating characteristic(ROC)curve was used to assess the diagnostic efficacy of PSAD in predicting benign and malignant prostate lesions in patients with category 3 of PI-RADS v2,and the optimal diagnostic threshold was also calculated.Results There were statistical significances in the parameter of age.prostate volume and PSAD between the two groups(P<0.05),however there was no statistical significance in PSA between the two groups(P>0.05).The area under the curve(AUC)value of PSAD was 0.827.When the threshold value was 0.205 ng/(mL·cm^(2)),the sensitivity and specificity of PSAD in the diagnosis of PCa and non-cancer patients with category 3 of PI-RADS v2 were 75%and 81.6%。respectively.Conclusion PSAD can ffetively improve the detection rate of PCa in patients with category 3 of P-RADS v2,and provide a basis for whether those patients ned a prostate biopsy.

关 键 词：前列腺癌 前列腺特异性抗原密度 前列腺影像报告和数据系统 

分 类 号：R737.25[医药卫生—肿瘤] R814.49[医药卫生—临床医学]