2017-2019年茂名市I4,[5],12:i:-沙门菌流行特征及耐药性分析  

Epidemiological characteristics and drug resistance analysis of Salmonella I4,[5],12∶I∶-in Maoming City from 2017 to 2019

作　　者：黄水飞[1] 彭淑萍[1] 许铭清[1] 廖国东[1] HUANG Shuifei;PENG Shuping;XU Mingqing;LIAO Guodong(Maoming Center for Disease Control and Prevention,Guangdong Maoming 525000,China)

机构地区：[1]茂名市疾病预防控制中心,广东茂名525000

出　　处：《中国食品卫生杂志》2020年第6期681-685,共5页Chinese Journal of Food Hygiene

摘　　要：目的了解茂名市I4,[5],12∶i∶-沙门菌的流行特征及耐药状况。方法利用血清学方法对I4,[5],12∶i∶-沙门菌进行鉴定,用微量肉汤稀释法对分离的I4,[5],12∶i∶-沙门菌进行抗生素敏感性检测。结果从患者粪便中分离的423株沙门菌中检出I4,[5],12∶i∶-沙门菌143株,检出率为33.81%,患者粪便主要来自<3岁婴幼儿,感染高峰为6~8月。耐药率最高为多西环素(97.90%,140/143),其次为四环素(95.10%,136/143)、磺胺异噁唑(93.71%,134/143)、氨苄西林(90.91%,130/143)、链霉素(86.71%,124/143)、米诺环素(83.22%,119/143)、氨苄西林/舒巴坦(58.74%,84/143)、氯霉素(58.74%,84/143)、磺胺甲噁唑/甲氧苄啶(53.85%,77/143)。敏感率最高为阿米卡星和美罗培南,均未发现耐药株(100.00%),其次为多黏菌素B(99.30%,142/143)、亚胺培南(99.30%,142/143)、头孢西丁(97.20%,139/143)、多黏菌素E(93.01%,133/143)、头孢他啶(92.31%,132/143)、阿奇霉素(92.31%,132/143)、头孢噻肟(81.82%,117/143)、头孢吡肟(79.72%,114/143)和氨曲南(79.72%,114/143)。共形成了97种耐药谱,多重耐药率达100.00%。结论I4,[5],12∶i∶-沙门菌婴幼儿感染率较高,耐药情况严峻。应扩大监测的哨点医院,加强沙门菌特别是I4,[5],12∶i∶-沙门菌的监测。碳青霉烯类抗生素和第二代、第三代、第四代头孢对I4,[5],12∶i∶-沙门菌敏感性较好,可作为治疗的首选用药。Objective To understand the epidemic characteristics and drug resistance of Salmonella I4, [5], 12∶I∶-in Maoming City. Methods Salmonella I4, [5], 12∶I∶-were identified by serological method, and then antibiotic sensitivity of isolated Salmonella I4, [5], 12∶I∶-was tested by broth microdilution method. Results Among 476 strains of Salmonella from patients’ feces, 143 strains of Salmonella I4, [5], 12∶I∶-were detected, and the detection rate was 33.81%. The feces of patients were mainly from infants <3 years old, the peak period mainly occurred from June to August. The rate of resistance to doxycycline was the highest(97.90%,140/143), followed by tetracycline(95.10%,136/143), sulfamethoxazole(93.71%,134/143), ampicillin(90.91%,130/143), streptomycin(86.71%,124/143), minocycline(83.22%,119/143), ampicillin/sulbactam(58.74%,84/143), chloramphenicol(58.74%,84/143) and sulfamethoxazole/trimethoprim(53.85%,77/143). Amikacin and meropenem were the most sensitive antibiotics, and no drug-resistant strains were found, followed by polymyxin B(99.30%,142/143), imipenem(99.30%,142/143), cefoxitin(97.20%,139/143), colistin(93.01%,133/143), ceftazidime(92.31%,132/143),azithromycin(92.31%,132/143), cefotaxime(81.82%,117/143), cefepime(79.72%,114/143)and aztreonam(79.72%,114/143). 97 kinds of drug resistance spectrum were identified, and the multi drug resistance rate was 100.00%. Conclusion Salmonella I4, [5], 12∶I∶-infection rate in infants is high, drug resistance is serious, and it is harmful to infants. It is necessary to expand the scope of sentinel hospitals and strengthen the surveillance of Salmonella, especially Salmonella I4, [5], 12∶I∶-. Salmonella I4, [5], 12∶I∶-was more sensitive to carbapenems and the second, third and fourth generation of cephalosporins which could be used as the first choice for treatment.

关 键 词：I4 [5] 12∶i∶-沙门菌 流行病学 耐药谱 多重耐药 

分 类 号：R155[医药卫生—营养与食品卫生学]