山鸡椒乙酸乙酯部位化学成分研究  

Chemical constituents from ethyl acetate soluble extraction of Litsea cubeba

作　　者：夏欢 王玲燕 夏桂阳 卫晓红 王亚男 林生 XIA Huan;WANG Ling-yan;XIA Gui-yang;WEI Xiao-hong;WANG Ya-nan;LIN Sheng(Key Laboratory of Chinese Internal Medicine of Ministry of Education arul Beijing,Dongzhimen Hospital,Beijing University of Chinese Medicine,Beijing 100700,China;State Key Laboratory of Bioactive Substance and Function of Natural Medicines,Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100050,China)

机构地区：[1]北京中医药大学东直门医院中医内科学教育部和北京市重点实验室,北京100700 [2]中国医学科学院北京协和医学院药物研究所天然药物活性物质与功能国家重点实验室,北京100050

出　　处：《中国中药杂志》2020年第24期5877-5883,共7页China Journal of Chinese Materia Medica

基　　金：国家自然科学基金项目(81903489,81522050)。

摘　　要：运用正相和反相硅胶柱色谱、凝胶柱色谱、大孔吸附树脂柱色谱、反相高效液相色谱等分离和纯化方法,结合MS和NMR等波谱技术,从山鸡椒乙醇提取物中的乙酸乙酯部位中分离鉴定了30个化学成分,包括1个倍半萜(1),4个单萜(2~5),2个丁内酯衍生物(6~7),7个酪胺衍生物(8~14),15个芳香类化合物(15~29)和1个吡喃酮类化合物(30),其中化合物1~7,13和14均为首次从该属植物中发现。Chemical investigation on the constituents of the ethyl acetate soluble extraction of Litsea cubeba has resulted in the isolation and structure elucidation of thirty compounds,including one sesquiterpene(1),four monoterpenes(2-5),twoγ-butyrolactone derivatives(6 and 7),seven tyramine derivatives(8-14),fifteen aromatic compounds(15-29),and one pyrone derivative(30)via various chromatographic techniques and spectroscopic data analysis(MS,IR,1 D and 2 D NMR).Compounds 1-7,13 and 14 were obtained from the genus Litsea for the first time.

关 键 词：木姜子属 山鸡椒 倍半萜 单萜 酪胺 

分 类 号：R284.1[医药卫生—中药学]