高级别B细胞淋巴瘤研究进展  

Progress of high-grade B-cell lymphoma

作　　者：白银银 干惠珠[1] 许新新 Bai Yinyin;Gan Huizhu;Xu Xinxin(Department of Hematology and Oncology,China-Japan Union Hospital of Jilin University,Changchun 130033,China)

机构地区：[1]吉林大学中日联谊医院血液肿瘤科,长春130033

出　　处：《白血病．淋巴瘤》2020年第12期765-768,共4页Journal of Leukemia & Lymphoma

摘　　要：高级别B细胞淋巴瘤(HGBL)传统上被用作侵袭性B细胞淋巴瘤的统称,这种B细胞淋巴瘤在形态学上表现出高级别特征,包括多个有丝分裂象、星空图案、较高的Ki-67等。但2016年世界卫生组织(WHO)淋巴瘤分类重新定义的HGBL包括伴有myc、bcl-2和(或)bcl-6重排的HGBL,也称为双重打击淋巴瘤(DHL)或三重打击淋巴瘤(THL)和不伴myc、bcl-2、bcl-6重排的HGBL,也称为HGBL,非特指型(HGBL-NOS)。HBGL具有高度侵袭性、疾病进展快、预后差、对常规化疗方案反应差等特点。准确地识别HGBL很重要,因为它可能会改变临床治疗方案。但经济有效的诊断方法及合理的治疗方案尚未达成一致的共识。文章对HGBL的生物学特征、诊断评估和最新治疗进展进行综述。High-grade B-cell lymphoma(HGBL)has been traditionally used as a general term for aggressive B-cell lymphoma,which shows high-level morphological features,including many mitotic figures,starry-sky pattern,high Ki-67,etc.However,the HGBL redefined by the World Health Organization(WHO)lymphoma classification in 2016 includes HGBL with myc,bcl-2 and/or bcl-6 rearrangement,which is also known as double-hit lymphoma(DHL)or triple-hit lymphoma(THL),and HGBL without myc,bcl-2 and bcl-6 rearrangement,also known as HGBL,not otherwise specified(HGBL-NOS).HBGL has the characteristics of high invasiveness,rapid disease progression,poor prognosis and poor response to conventional chemotherapy.Accurate identification of HGBL is important because it may change the clinical treatment plan.However,there is no consensus on the cost-effective diagnostic methods and reasonable treatment plans.This article reviews the biological characteristics,diagnostic evaluation and latest treatment progress of HGBL.

关 键 词：淋巴瘤 B细胞 基因重排 B淋巴细胞 MYC基因 BCL-2基因 BCL-6基因 

分 类 号：R733.1[医药卫生—肿瘤]