霉酚酸酯的临床应用进展  

Recent advances in clinical application of mycophenolate mofetil

作　　者：方丽纳 张博 平丽英 张薇[1] 周屹峰[1] 柳志强 FANG Lina;ZHANG Bo;PING Liying;ZHANG Wei;ZHOU Yifeng;LIU Zhiqiang(Hangzhou Zhongmei Huadong Pharmaceutical Co.,Ltd.,Hangzhou 310011,China;College ofBiotechnology and Bioengineering,Zhejiang University of Technology,Hangzhou 310014,China)

机构地区：[1]杭州中美华东制药有限公司,浙江杭州310011 [2]浙江工业大学生物工程学院,浙江杭州310014

出　　处：《发酵科技通讯》2021年第1期14-19,共6页Bulletin of Fermentation Science and Technology

基　　金：浙江省重点研发计划项目(2019C03087)。

摘　　要：霉酚酸酯作为第3类免疫抑制剂的主力之一,临床主要用于器官移植后预防急性排斥反应,提高移植器官的存活率。在众多免疫抑制剂中因霉酚酸酯具有选择性强、毒副作用小及复发率低等优势而广泛应用于临床。此外,霉酚酸酯常与其他类型免疫剂或激素联用,在自身免疫性疾病、并发症引起的肾炎、原发性肾病综合症、结节病、皮肤病及眼科疾病等方面带来很好的治疗效果。笔者从药代动力学和临床应用两个方面进行综述,为霉酚酸酯的进一步开发与合理利用提供依据。Mycophenolate mofetil,one of the third immunosuppressants,mainly used to prevent acute rejection and improve the survival rate of transplanted organs after organ transplantation.Mycophenolate mofetil is widely used in many immunosuppressants because of its advantages of high selectivity,low toxicity,and low recurrence rate.Mycophenolate mofetil is often combined with other types of immune agents or hormones,which can bring good therapeutic effect in autoimmune diseases,complications-caused nephritis,primary nephrotic syndrome,sarcoidosis,skin diseases,and ophthalmic diseases.In this review,the authors summarized pharmacokinetics and clinical application to provide a basis for further development and rational utilization of mycophenolate mofetil.

关 键 词：霉酚酸酯 免疫抑制剂 临床 

分 类 号：R979.5[医药卫生—药品]