甲状腺乳头状癌中肿瘤相关巨噬细胞浸润及CD47表达的意义  

Significance of tumor-associated macrophages infiltration and CD47 expression in papillary thyroid cancer

作　　者：刘志敏[1] 刘天卿[1] 王红龙 刘楠[2] LIU Zhimin;LIU Tianqing;WANG Honglong;LIU Nan(Department of Pathology, Dalian Municipal Friendship Hospital, Dalian 116001, China;Department of Endocrinology, the Second Affiliated Hospital of Dalian Medical University, Dalian 116027, China)

机构地区：[1]大连市友谊医院病理科,辽宁大连116001 [2]大连医科大学附属第二医院内分泌1科,辽宁大连116027

出　　处：《大连医科大学学报》2021年第1期20-24,共5页Journal of Dalian Medical University

摘　　要：目的探讨肿瘤相关巨噬细胞浸润及CD47蛋白表达与甲状腺乳头状癌患者临床病理特征间的关系及意义。方法收集大连市友谊医院2015—2019年间甲状腺乳头状癌手术切除标本65例,应用免疫组织化学方法检测所有标本中CD68+和CD163+肿瘤相关巨噬细胞浸润和CD47蛋白表达情况,分析肿瘤相关巨噬细胞浸润、CD47蛋白表达与甲状腺乳头状癌患者临床病理特征间的关系,以及肿瘤相关巨噬细胞与CD47蛋白表达的相关性。结果CD68+肿瘤相关巨噬细胞阳性率为35.38%,与肿瘤体积及淋巴结转移有关(P<0.05);CD163+肿瘤相关巨噬细胞阳性率为16.92%,与癌侵犯甲状腺外组织情况有关(P<0.05)。CD47蛋白阳性表达率为20.00%。CD68+和CD163+肿瘤相关巨噬细胞浸润与CD47表达均无关联(P>0.05)。结论CD68+肿瘤相关巨噬细胞可能促进甲状腺乳头状癌进展,而CD163+肿瘤相关巨噬细胞可能抑制其进展。Objective To explore the significance of tumor-associated macrophages(TAMs)infiltration and CD47 protein expression in papillary thyroid cancer(PTC).Methods A total of 65 cases of PTC specimens were collected in Dalian Municipal Friendship Hospital during 2015-2019.Immunohistochemical staining was used to detect the infiltration of CD68+and CD163+TAMs,and the expression of CD47 protein in all specimens.The relationships between CD68+TAMs infiltration,CD163+TAMs infiltration,CD47 protein expression and clinicopathological features of PTC patients,and correlations of CD68+TAMs and CD163+TAMs with CD47 protein in PTC were analyzed.Results TAMs with CD68 positive(35.38%)was associated with tumor size and lymph node metastasis(P<0.05).TAMs with CD163 positive(16.92%)was associated with extrathyroidal extension situation(P<0.05).CD47 protein expression(20.00%)had no relevance with CD68+TAMs or CD163+TAMs infiltration(P>0.05).Conclusions The CD68+TAMs may play a promotive role in PTC progression,however CD163+TAMs may play a suppressive one.

关 键 词：甲状腺乳头状癌 CD68+肿瘤相关巨噬细胞 CD163+肿瘤相关巨噬细胞 CD47 

分 类 号：R736.1[医药卫生—肿瘤]