消栓颗粒治疗颈动脉斑块患者的临床疗效分析  

Analysis of the clinical efficacy of Xiaoshuan granule in the treatment of patients with carotid plaque

作　　者：邓毅[1] 刘霄[1] 韩毅[1] 周瑾[1] DENG Yi;LIU Xiao;HAN Yi(Department of Neurology,Xinhua Hospital Affiliated to Dalian University,Dalian 116021,China)

机构地区：[1]大连大学附属新华医院神经内二科,116021

出　　处：《中国现代药物应用》2021年第5期32-34,共3页Chinese Journal of Modern Drug Application

摘　　要：目的探讨消栓颗粒治疗颈动脉斑块患者的临床疗效。方法156例颈动脉斑块患者,随机分为对照组和观察组,各78例。对照组给予常规西药治疗,观察组在对照组基础上采用消栓颗粒治疗。比较两组患者治疗前后神经功能缺损情况及颈动脉内中膜厚度(IMT)、斑块面积、颈总动脉内径(CAD)。结果治疗前,两组患者肢体无力、麻木、疼痛、构音障碍及视力下降发生率比较差异无统计学意义(P>0.05);治疗后,观察组肢体无力、麻木、疼痛及视力下降发生率分别为2.56%、1.28%、1.28%、1.28%,均低于对照组的11.54%、8.97%、8.97%、8.97%,差异有统计学意义(P<0.05)。治疗后,观察组IMT(1.25±0.21)mm、斑块面积(31.20±3.28)mm~2、CAD(4.25±0.47)mm均显著小于对照组的(1.59±0.83)mm、(36.29±2.84)mm~2、(5.25±0.23)mm,差异有统计学意义(P<0.05)。结论采用消栓颗粒对颈动脉斑块患者进行治疗,其能够有效改善患者神经功能缺损情况及颈总动脉情况,预后良好,值得推广应用。Objective To discuss the clinical efficacy of Xiaoshuan granule in the treatment of patients with carotid plaque.Methods A total of 156 patients with carotid plaque were randomly divided into control group and observation group,with 78 cases in each group.The control group was treated with conventional Western medicine,and the observation group was treated with Xiaoshuan granule based on the control group.The neurological deficits,carotid artery intima-media thickness(IMT),plaque area,and common carotid artery diameter(CAD)before and after treatment were compared between the two groups.Results Before treatment,there was no statistically significant difference in the incidence of limb weakness,numbness,pain,dysarthria and vision loss between the two groups(P>0.05);after treatment,the incidence of limb weakness,numbness,pain and vision loss in the observation group was 2.56%,1.28%,1.28%and 1.28%,which were lower than 11.54%,8.97%,8.97%and 8.97%in the control group,and the difference was statistically significant(P<0.05).After treatment,the IMT(1.25±0.21)mm,plaque area(31.20±3.28)mm~2 and CAD(4.25±0.47)mm of the observation group were significantly smaller than(1.59±0.83)mm,(36.29±2.84)mm~2 and(5.25±0.23)mm of the control group,and the difference was statistically significant(P<0.05).Conclusion Xiaoshuan granules can improve the neurological deficits in the clinical treatment of patients with carotid plaqueand common carotid artery.The prognosis is good and it is worthy of promotion and application.

关 键 词：消栓颗粒 颈动脉斑块 常规治疗 临床疗效 

分 类 号：R743.3[医药卫生—神经病学与精神病学]