脑卒中后继发癫痫应用奥卡西平治疗的效果及安全性分析  

Analysis of the efficacy and safety of oxcarbazepine in the treatment of secondary epilepsy after stroke

作　　者：安太健[1] AN Tai-jian(Department Two of Encephalopathy Rehabilitation,Affiliated Hospital of Liaoning University of Traditional Chinese Medicine,Shenyang 110032,China)

机构地区：[1]辽宁中医药大学附属医院脑病康复二科,110032

出　　处：《中国现代药物应用》2021年第5期100-103,共4页Chinese Journal of Modern Drug Application

摘　　要：目的探讨脑卒中后继发癫痫患者应用奥卡西平治疗的效果及安全性。方法60例脑卒中后继发癫痫患者,随机分为试验组和对照组,各30例。试验组采用奥卡西平治疗,对照组采用卡马西平治疗。比较两组患者治疗后血脂指标,治疗效果,治疗后脑电图情况,不良反应发生情况。结果试验组患者治疗后血清总胆固醇、甘油三酯和低密度脂蛋白胆固醇水平均低于对照组,高密度脂蛋白胆固醇水平高于对照组,差异有统计学意义(P<0.05)。试验组患者治疗后总有效率为90.00%,高于对照组的56.67%,差异有统计学意义(P<0.05)。试验组患者治疗后痫样放电(7.60±0.72)t/180 s、累及导联数(3.82±0.13)/180 s均少于对照组的(11.21±0.77)t/180 s、(5.25±0.11)/180 s,差异有统计学意义(P<0.05)。试验组患者不良反应发生率为6.67%,低于对照组的20.00%,差异有统计学意义(P<0.05)。结论脑卒中后继发癫痫患者采用奥卡西平治疗的效果和安全性均明显优于卡马西平,且不影响患者的血脂情况,值得临床推广。Objective To discuss the efficacy and safety of oxcarbazepine in the treatment of secondary epilepsy after stroke.Methods A total of 60 patients with secondary epilepsy after stroke were randomly divided into experimental group and control group,with 30 cases in each group.The experimental group was treated with oxcarbazepine,and the control group was treated with carbamazepine.The blood lipid index,treatment effect,electroencephalogram and occurrence of adverse reactions after treatment were compared between the two groups.Results After treatment,the serum total cholesterol,triglyceride and low density lipoprotein cholesterol of the experimental group were lower than those of the control group,and high density lipoprotein cholesterol was higher than that of the control group.The difference was statistically significant(P<0.05).After treatment,the total effective rate of the experimental group was 90.00%,which was higher than 56.67%of the control group,and the difference was statistically significant(P<0.05).After treatment,the epileptiform discharge(7.60±0.72)t/180 s and number of leads involved(3.82±0.13)/180 s of the experimental group were less than(11.21±0.77)t/180 s and(5.25±0.11)/180 s of the control group,and the difference was statistically significant(P<0.05).The incidence of adverse reactions of the experimental group was 6.67%,which was lower than 20.00%of the control group,and the difference was statistically significant(P<0.05).Conclusion Oxcarbazepine has obviously better effect and safety than carbamazepine in the treatment of patients with secondary epilepsy after stroke,and it does not affect the patient’s blood lipids,which is worthy of clinical promotion.

关 键 词：脑卒中 继发癫痫 奥卡西平 卡马西平 

分 类 号：R742.1[医药卫生—神经病学与精神病学] R743.3[医药卫生—临床医学]