Pokemon、TIP30和HCCR-1在直肠癌组织中的表达及预后的关系研究  

Expression of Pokemon,TIP30 and HCCR⁃1 in rectal cancer and their relationship with prognosis

作　　者：樊丽伟 古彩喆 赵彦焕 李洵[1] 付晓霞[1] 张磊[1] 汪景坤 张东娇[1] FAN Liwei;GU Caizhe;ZHAO Yanhuan;LI Xun;FU Xiaoxia;ZHANG Lei;WANG Jingkun;ZHANG Dongjiao(Hospital of the 82nd Group Army of PLA,Baoding,Hebei,China,071000)

机构地区：[1]中国人民解放军陆军第八十二集团军医院消化内科,河北保定071000

出　　处：《分子诊断与治疗杂志》2021年第2期220-224,共5页Journal of Molecular Diagnostics and Therapy

基　　金：保定市科技计划项目(1941ZF098)。

摘　　要：目的探讨Pokemon、TIP30和人宫颈癌基因-1(HCCR-1)在直肠癌组织中的表达及预后的关系。方法纳入100例2016年6月至2018年6月本院收治的直肠癌患者,收集术中切取的100份直肠癌组织及癌旁组织。采用免疫组织化学方法检测Pokemon、TIP30及HCCR-1蛋白的表达水平。比较Pokemon、TIP30及HCCR-1不同表达水平患者临床资料的差异。对患者进行随访2年,采用多元Logistic回归分析影响直肠癌患者预后生存的危险因素,绘制Kaplan-Meier生存曲线,研究Pokemon、TIP30及HCCR-1蛋白表达情况对直肠癌患者预后生存的影响。结果直肠癌组织中Pokemon、HCCR-1蛋白表达水平显著高于癌旁组织,而TIP30蛋白表达水平显著低于癌旁组织,差异有统计学意义(P<0.05);年龄、性别、局部浸润程度与直肠癌患者组织Pokemon、TIP30及HCCR-1蛋白表达无相关(P>0.05),但Dukes分期、淋巴结转移与Pokemon、HCCR-1蛋白表达呈正相关,而组织分化程度与TIP30蛋白表达呈负相关(P<0.05);100例直肠癌患者2年生存率为43.00%(43/100)。Dukes分期、淋巴结转移、分化程度、Pokemon高表达、TIP30低表达及HCCR-1高表达为影响直肠癌患者预后生存的独立危险因素(P<0.05)。Pokemon、HCCR-1蛋白低表达组平均生存时间显著长于高表达组,TIP30蛋白高表达组平均生存时间显著长于低表达组,差异有统计学意义(P<0.05)。结论 Pokemon、HCCR-1、TIP30与在直肠癌患者组织中密切相关,可作为预测直肠癌患者预后的分子标志物和肿瘤治疗的潜在靶点。Objective To investigate the the expression of Pokemon,TIP30 and HCCR⁃1 in rectal cancer and their relationship with prognosis.Methods 100 patients with rectal cancer who were admitted to this hospital from June 2016 to June 2018 were enrolled.100 rectal cancer tissues and adjacent tissues were col⁃lected during the operation.Immunohistochemical methods were used to detect the expression levels of Poke⁃mon,TIP30 and HCCR⁃1 proteins.The differences in the clinical data of patients with different expressions of Pokemon,TIP30 and HCCR⁃1 were compared.All patients were followed up for 2 years after the treatment.Multivariate Logistic regression was used to analyze the risk factors affecting the prognosis of patients with rec⁃tal cancer.Kaplan⁃Meier survival curve was drawn to study the effects of Pokemon,TIP30 and HCCR⁃1 protein expressions on the prognosis of patients with rectal cancer.Results The Pokemon and HCCR⁃1 proteins in rec⁃tal cancer tissues were significantly higher than those in precancerous tissues,and the TIP30 protein was lower than that in precancerous tissues,and the differences were statistically significant(P<0.05).There was no sig⁃nificant correlation between age,gender,and the degree of local infiltration and the Pokemon,TIP30,and HC⁃CR⁃1 protein in patients with rectal cancer(P>0.05),but Dukes staging,lymph node metastasis,Pokemon,and HCCR⁃1 protein expression are positively correlated.The degree of tissue differentiation and TIP30 protein expression were negatively correlated(P<0.05).The 2⁃year survival rate of 100 patients with rectal cancer was 43.00%(43/100).Dukes staging,lymph node metastasis,degree of differentiation,high expression of Poke⁃mon and HCCR⁃1,and low expression of TIP30 were independent risk factors affecting the prognosis and sur⁃vival of patients with rectal cancer(P<0.05).The average survival time of the Pokemon and HCCR⁃1 protein low expression group was longer than that of the high expression group,and the average survival time of th

关 键 词：POKEMON TIP30 HCCR-1 直肠癌 

分 类 号：R735.37[医药卫生—肿瘤]