MMP-2、PCNA及Syndecan-1与口腔黏膜鳞状细胞癌进展的关系研究  

Study on the relationship between MMP⁃2,PCNA,Syndecan⁃1 and the progression of oral squamous cell carcinoma

作　　者：郑朝辉 刘春丽 曹瑞 郝立辉[2] ZHNEG Chaohui;LIU Chunli;CAO Rui;HAO Lihui(Department of Stomatology,Second Affiliated Hospital of Xingtai Medical College,Xingtai,Hebei,China,054000;Department of Stomatology,Hebei Xingtai Medical College,Xingtai,Hebei,China,054000)

机构地区：[1]邢台医专第二附属医院口腔科,河北邢台054000 [2]河北邢台医学高等专科学校口腔系,湖北邢台054000

出　　处：《分子诊断与治疗杂志》2021年第2期263-266,共4页Journal of Molecular Diagnostics and Therapy

基　　金：邢台市科技计划项目(2020ZC166)。

摘　　要：目的探讨基质金属蛋白酶2(MMP-2)、增殖细胞核抗原(PCNA)及蛋白聚糖-1(Syndecan-1)在口腔黏膜鳞状细胞癌中的表达及其与疾病进展的关系。方法收集2015年2月至2018年2月本院收治的62例口腔粘膜鳞状细胞癌患者标本设为观察组,选取上述患者癌旁正常组织设为对照组,对比MMP-2、PCNA及Syndecan-1在不同组织中的表达情况,分析三者与病理特征的关系并探讨三者不同表达对患者预后2年生存情况的预测价值。结果观察组MMP-2、PCNA阳性表达率显著高于对照组,Syndecan-1阳性表达率显著低于对照组,差异均具有统计学意义(P<0.05)。MMP-2、PCNA及Syndecan-1与淋巴结转移(有)、肿瘤直径(≥3 cm)、组织分化程度(低-中分化),TNM分期(Ⅲ~Ⅳ期)有关(P<0.05)。本研究纳入的62例口腔粘膜鳞状细胞癌患者2年生存率为40.32%(25/62),MMP-2阳性、PCNA阳性及Syndecan-1阴性的患者死亡率更高(P<0.05)。MMP-2、PCNA、Syndecan-1及三者联合ROC曲线下面积分别为0.811、0.730、0.814、0.917,各指标曲线下面积以三者联合检测最大。结论 MMP-2及PCNA表达阳性、Syndecan-1表达阴性的口腔黏膜鳞状细胞癌患者死亡率更高,可联合三者检测水平了解疾病进展情况,评估预后。Objective To investigate the expression of matrix metalloprotein⁃2(MMP⁃2),prolif⁃erating cell nuclear antigen(PCNA)and proteoglycan⁃1(Syndecan⁃1)in oral mucosal squamous cell carcino⁃ma and its relationship with disease progression.Method The clinical data of 62 patients with oral mucosal squamous cell carcinoma admitted to our hospital from February 2015 to February 2018 were selected.62 speci⁃mens of oral mucosal squamous cell carcinoma were set as the observation group,and the normal tissues adja⁃cent to the cancer were selected as the control group.The expressions of MMP⁃2,PCNA and Syndecan⁃1 in different tissues were measured and compared.The relationship between the them and the pathological charac⁃teristics was analyzed,and the predictive value of the three expressions for the patient's 2⁃year survival status was explored.Results①The positive expression rate of MMP⁃2 and PCNA in the observation group was significantly higher than that in the control group,and the positive expression rate of Syndecan⁃1 was signifi⁃cantly lower than that in the control group,and the difference was statistically significant(P<0.05).②MMP⁃2,PCNA and Syndecan⁃1 are related to lymph node metastasis(yes),tumor diameter(≥3 cm),degree of tissue differentiation(low⁃medium differentiation),and TNM staging(stageⅢ~Ⅳ)(P<0.05).③The 2⁃year survival rate of 62 patients with oral mucosal squamous cell carcinoma included in this study was 40.32%(25/62).The mortality of patients with positive MMP⁃2,PCNA,and negative Syndecan⁃1 expression was high⁃er(P<0.05).④The area under the ROC curve of MMP⁃2,PCNA,Syndecan⁃1 and the combined indicators were 0.811,0.730,0.814,0.917,respectively.The area under the combined detection curve was the highest.Conclusion Patients with oral mucosal squamous cell carcinoma with positive expression of MMP⁃2 and PC⁃NA and negative expression of Syndecan⁃1 have a higher mortality rate.The detection level of the three indica⁃tors can be combined to und

关 键 词：MMP-2 PCNA SYNDECAN-1 口腔黏膜鳞状细胞癌 

分 类 号：R739.8[医药卫生—肿瘤]