小分子化合物抗牙菌斑生物膜的研究进展  

Research Progress of Small Molecule Compounds Against Dental Plaque Biofilm

作　　者：张瑾 徐欣[1] ZHANG Jin;XU Xin(State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Department of Conservative Dentistry and Endodontics, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China)

机构地区：[1]口腔疾病研究国家重点实验室,国家口腔疾病临床医学研究中心,四川大学华西口腔医院牙体牙髓科,四川成都610041

出　　处：《口腔医学研究》2021年第3期204-207,共4页Journal of Oral Science Research

基　　金：国家自然科学基金(编号:81771099)。

摘　　要：牙菌斑生物膜是引起龋病和牙周病的主要原因,生物膜中的细菌对抗生素和宿主防御的抵抗力显著高于浮游细菌。传统去除生物膜的方法存在许多不足之处,小分子化合物因细胞渗透性强和合成简单等优点,成为近年来研发生物膜抑制剂的热点。目前已经发现的小分子抗牙菌斑生物膜的化合物大致可分为三类:群体感应抑制剂、细菌粘附抑制剂和关键致病毒力因子抑制剂。本文对近年来小分子化合物在抗牙菌斑生物膜领域的研究进展作一综述。Dental plaque biofilm is the main cause of dental caries and periodontal diseases.The resistance of bacteria in biofilm to antibiotics and host defense is higher than that of planktonic bacteria.There are many shortcomings in the traditional methods to remove biofilm,so the research focus turns to small molecule compounds because they are cell permeable and easily synthesized.The small molecule antibiofilm compounds can be roughly divided into three categories:quorum-sensing inhibitors,bacterial adhesion inhibitors,and crucial virulence factor inhibitors.In this paper,the research progress of small molecule compounds against dental plaque biofilm in recent years is reviewed.

关 键 词：小分子化合物 牙菌斑生物膜 龋病 牙周病 

分 类 号：R78[医药卫生—口腔医学]