萘普生钠联合磷酸可待因用于下颌阻生智齿拔除术后镇痛消肿的疗效评价  

Efficacy of Naproxen Sodium Combined with Codeine Phosphate on Pain and Edema following Extraction of Mandibular Impacted Wisdom Tooth

作　　者：谢宏亮 汤剑明 路璐 李博涵 王萌萌 XIE Hongliang;TANG Jianming;LU Lu;LI Bohan;WANG Mengmeng(Department of Oral and Maxillofacial Surgery, Stomatological Medical Center, Shenzhen People's Hospital, The First Affiliated Hospital of South University of Science and Technology, The Second Clinical Medical College of Ji’Nan University, Shenzhen 518020, China)

机构地区：[1]南方科技大学第一附属医院,暨南大学第二临床医学院,深圳市人民医院,口腔医学中心口腔颌面外科,广东深圳518020

出　　处：《口腔医学研究》2021年第3期242-245,共4页Journal of Oral Science Research

摘　　要：目的:比较萘普生钠联合磷酸可待因、洛索洛芬和布洛芬对下颌阻生智齿拔除术后镇痛消肿的临床疗效。方法:90例拔除下颌阻生智齿的患者按随机双盲法分为3组。在拔牙前1 h及术后第2~7天分别服用萘普生钠+磷酸可待因、洛索洛芬和布洛芬。对术后疼痛、肿胀和张口度进行观察和统计分析。结果:萘普生钠+磷酸可待因对疼痛、肿胀和张口受限的治疗效果更好(P<0.05);洛索洛芬和布洛芬临床效果相似(P>0.05)。结论:萘普生钠+磷酸可待因可作为治疗下颌阻生智齿拔除术后疼痛、肿胀和张口受限较好的选择。Objective:To compare the clinical efficacies of naproxen sodium combined with codeine phosphate,losoprofen,and ibuprofen in the treatment of pain and edema following mandibular impacted wisdom tooth extraction.Methods:90 healthy volunteers who asked impacted wisdom tooth extraction were randomly distributed into three groups.1 hour before and 2 to 7 days after tooth extraction,patients were administrated separatly with naproxen sodium+codeine phosphate tablet,losuprofen,or ibuprofen.The postoperative pain,edema,and trismus were recorded and analyzed.Results:Naproxen sodium combined with codeine phosphate was found to be more effective for pain,edema,and trismus compared to losuprofen and ibuprofen(P<0.05).Losuprofen yielded similar clinical responses to ibuprofen(P>0.05).Conclusion:Naproxen sodium combined with codeine phosphate can be used as a better choice for the treatment of pain,edema,and trismus after mandibular impacted wisdom tooth extraction.

关 键 词：萘普生钠 磷酸可待因 阻生智齿 镇痛 

分 类 号：R78[医药卫生—口腔医学]