颌面部血管瘤患者瘤腔内注射平阳霉素联合介入栓塞治疗的有效性及安全性研究  

Efficacy and Safety of Intraluminal Injection of Pingyangmycin combined with Interventional Embolization in Maxillofacial Hemangioma Patients

作　　者：林琦[1] 范好好 钱丽伟 张巧荣[1] LIN Qi;FAN Haohao;QIAN Liwei(Henan People's Hospital,Zhengzhou,450003)

机构地区：[1]河南省人民医院,450003

出　　处：《实用癌症杂志》2021年第2期256-259,共4页The Practical Journal of Cancer

摘　　要：目的探讨颌面部血管瘤患者瘤腔内注射平阳霉素联合介入栓塞治疗的有效性及安全性。方法选取诊治的颌面部血管瘤患者100例,随机分为对照组与观察组,每组50例,对照组采取瘤腔内注射平阳霉素治疗,观察组采取瘤腔内注射平阳霉素联合介入栓塞治疗,观察两组治疗前、治疗后1个月、3个月、6个月时的血管瘤面积变化,术中及术后并发症发生情况,患者对治疗效果的满意度及评定治疗疗效。结果两组瘤体面积治疗后与治疗前比较面积缩小(P<0.001),且观察组治疗后1个月、3个月、6个月时瘤体面积明显小于对照组(P<0.001);两组患者术中均未出现过敏性休克等并发症,均完成治疗,对照组术后并发症发生率为6.00%,观察组为10.00%,比较差异有统计学意义(P>0.05);观察组患者对治疗后的皮肤颜色、瘤体缩小程度、整体效果的满意度评分均高于对照组,比较差异有统计学意义(P<0.001);两组治疗整体疗效比较差异有统计学意义(P<0.05),对照组治疗总有效率为78.00%,观察组为94.00%,总有效率间比较差异有统计学意义(P<0.05)。结论颌面部血管瘤患者采取瘤腔内注射平阳霉素联合介入栓塞治疗疗效显著,安全可靠。Objective To investigate the efficacy and safety of intraluminal injection of pingyangmycin combined with interventional embolization in maxillofacial hemangioma patients.Methods 100 cases of maxillofacial hemangioma patients were randomly divided into the control group and the observation group,50 cases in each group,the control group was treated with intraluminal injection of pingyangmycin,the observation group was treated with intraluminal injection of pingyangmycin combined with interventional embolization,to observed the changes of hemangioma area before and after treatment at 1 month,3 months and 6 months,the occurrence of intraoperative and postoperative complications,the patients'satisfaction with the therapeutic effect and evaluation of the therapeutic effect.Results The tumor area of the 2 groups decreased after treatment compared with before treatment(P<0.001),the tumor area of the observation group was significantly smaller than that of the control group after treatment at 1 month,3 months and 6 months(P<0.001).No complications such as anaphylactic shock were found in the 2 groups,the incidence of postoperative complications was 6.00%in the control group and 10.00%in the observation group,the difference was statistically significant(P>0.05).The skin color,tumor size and overall satisfaction score of the observation group were all higher than that of the control group after treatment(P<0.001).There was a statistically significant difference in the overall therapeutic effect between the 2 groups(P<0.05),the total effective rate was 78.00%in the control group and 94.00%in the observation group,the difference was statistically significant(P<0.05).Conclusion The intraluminal injection of pingyangmycin combined with interventional embolization in maxillofacial hemangioma patients is effective,safe and reliable.

关 键 词：颌面部 血管瘤 平阳霉素 介入栓塞 有效性 安全性 

分 类 号：R739.81[医药卫生—肿瘤]