胰头十二指肠切除术联合替吉奥治疗胰腺癌对患者血清MIC-1、REG4水平的影响  

Effects of Pancreaticoduodenectomy combined with S-1 on Serum Levels of MIC-1,REG4 in Patients with Pancreatic Cancer

作　　者：吉文伟 魏璐璐[1] 郭胜利[1] 宋展[1] JI Wenwei;WEI Lulu;GUO Shengli(Central Hospital of Nanyang,Nanyang,473000)

机构地区：[1]河南省南阳市中心医院,473000

出　　处：《实用癌症杂志》2021年第2期308-311,共4页The Practical Journal of Cancer

摘　　要：目的探讨胰头十二指肠切除术联合替吉奥治疗胰腺癌对患者血清MIC-1、REG4水平的影响。方法回顾性分析110例胰腺癌行胰头十二指肠切除术后患者的临床资料,按术后辅助化疗方式的不同,分为观察组和对照组,各55例。对照组用吉西他滨辅助化疗,观察组用替吉奥辅助化疗,2组均连续治疗2个疗程。比较2组化疗前后血清肿瘤标志物水平、血清MIC-1、REG4水平、生活质量评分;比较2组化疗期间不良反应发生情况;比较2组随访4、8、12个月的平均生存期及生存率。结果与化疗前相比,化疗后2组血清肿瘤标志物CA19-9、CA50、CA125、CA242水平,血清MIC-1、REG4水平均降低,且观察组低于对照组。与化疗前相比,2组化疗后1、4、10周的生活质量评分逐渐升高,且观察组高于对照组。化疗期间,观察组不良反应总发生率(32.73%)低于对照组(52.73%)。观察组患者随访4、8、12个月平均生存期长于对照组;观察组患者随访12个月的生存率高于对照组(P均<0.05)。结论胰头十二指肠切除术后替吉奥辅助化疗可降低胰腺癌患者血清MIC-1、REG4水平,抑制肿瘤细胞分化,有利于患者预后,可延长患者生存周期并提高生活质量。Objective To analyze the effects of pancreaticoduodenectomy combined with S-1 on serum levels of MIC-1,REG4 in patients with pancreatic cancer.Methods To retrospectively analyze the clinical data of 110 patients with pancreatic cancer who underwent pancreaticoduodenectomy,according to the different postoperative adjuvant chemotherapy methods,the patients were divided into the observation group and the control group,with 55 cases in each group.The control group received gemcitabine adjuvant chemotherapy and the observation group received S-1 adjuvant chemotherapy,the 2 groups received 2 courses of continuous treatment.The serum tumor marker levels,serum MIC-1,REG4 levels,and the quality of life scores before and after chemotherapy were compared between the 2 groups;the incidence of adverse reactions during chemotherapy was compared between the 2 groups;the mean survival and survival rates of the 2 groups were compared at 4,8 and 12 months of followed up.Results Compared with before chemotherapy,the serum levels of tumor markers CA19-9,CA50,CA125,CA242,the serum levels of MIC-1,REG4 decreased in the 2 groups after chemotherapy,and the observation group was lower than the control group;Compared with before chemotherapy,the quality of life scores of the 2 groups at 1,4 and 10 weeks after chemotherapy gradually increased,and the observation group was higher than the control group;During chemotherapy,the total incidence of adverse reactions in the observation group(32.73%)was lower than that in the control group(52.73%);Patients in the observation group were followed up for 4,8,and 12 months,and the average survival time was longer than those in the control group;the survival rate of patients in the observation group was higher than that of the control group after 12 months of followed up(P<0.05).Conclusion S-1 adjuvant chemotherapy after pancreaticoduodenectomy could reduce serum levels of MIC-1,REG4 in patients with pancreatic cancer,inhibit tumor cell differentiation,facilitate the prognosis of patients,prolong the

关 键 词：胰腺癌 胰头十二指肠切除术 替吉奥 化疗 巨噬细胞抑制因子-1 胰腺再生蛋白Ⅳ 预后 

分 类 号：R735.9[医药卫生—肿瘤]