两种门冬酰胺酶治疗儿童急性淋巴细胞白血病的近期效果及对患儿血清LDH、SF和ESR的影响  

Study on the Effects of Two Asparaginases on the Short-term Prognosis and Serum LDH,SF and ESR of Children with Acute Lymphoblastic Leukemia

作　　者：陈娜 宋春兰 景钰 靳玲云 CHEN Na;SONG Chunlan;JING Yu(Henan Children's Hospital,Zhengzhou Children's Hospital,Zhengzhou,450000)

机构地区：[1]河南省儿童医院、郑州儿童医院,450000

出　　处：《实用癌症杂志》2021年第2期337-340,共4页The Practical Journal of Cancer

摘　　要：目的比较左旋门冬酰胺酶、培门冬酶治疗儿童急性淋巴细胞白血病的近期效果及对患儿血清乳酸脱氢酶(LDH)、铁蛋白(SF)和血沉(ESR)的影响。方法将急性淋巴细胞白血病患儿86例随机均分为2组,对照组43例应用左旋门冬酰胺酶治疗,观察组43例应用培门冬酶治疗。比较2组的近期疗效,血常规,血清LDH、SF和ESR,住院时间和用药频次,不良反应发生情况。结果观察组近期总有效率为95.3%(41/43),略高于对照组的90.7%(39/43),但差异无统计学意义(P>0.05)。治疗前2组血红蛋白(Hb)、白细胞计数(WBC)、红细胞计数(RBC)、血小板计数(PLT)比较差异均无统计学意义(P>0.05),治疗后2组患儿血常规指标均有所改善,但2组间差异仍无统计学意义(P>0.05)。治疗前2组血清LDH、SF和ESR比较差异无统计学意义(P>0.05),治疗后2组以上各指标均明显降低,并且观察组血清LDH、SF和ESR显著低于对照组(P<0.05)。观察组住院时间显著短于对照组,用药次数显著少于对照组(P<0.05)。观察组过敏反应、低白蛋白血症发生率显著低于对照组(P<0.05)。结论左旋门冬酰胺酶、培门冬酶对儿童急性淋巴细胞白血病的近期效果均较满意,能够显著改善患儿的血常规、血生化指标,但培门冬酶能够更好地改善血清LDH、SF和ESR水平,并且住院时间更短、用药频次更少,可以有效降低过敏反应、低白蛋白血症的不良反应发生率,更为安全有效。Objective To investigate the effects of two asparaginases on the short-term prognosis and serum LDH,SF and ESR of children with acute lymphoblastic leukemia.Methods 86 cases of children with acute lymphoblastic leukemia diagnosed and treated were randomly divided into 2 groups,43 cases in the control group were treated with L-asparaginase,and 43 cases in the observation group were treated with Pegaspargase.The short-term curative effects,blood routine,serum LDH,SF and ESR,length of hospital stay and frequency of medication,and adverse reactionsoccurrence of the 2 groups were compared.ResultsThe short-term total effective rate of the observation group was 95.3%(41/43),slightly higher than 90.7%(39/43)of the control group,but the difference between the 2 groups was not statistically significant(P>0.05).There was no significant difference in hemoglobin(Hb),white blood cell count(WBC),red blood cell count(RBC),platelet count(PLT)between the 2 groups before treatment(P>0.05),after treatment,the blood routine indexes of the 2 groups were different improved,but the differences between the 2 groups were not statistically significant(P>0.05).Before treatment,there was no significant difference in serum LDH,SF and ESR between the 2 groups(P>0.05),after treatment,the above indicators of the 2 groups were significantly reduced,and the serum LDH,SF and ESR of the observation group were significantly lower than those of the control group(P<0.05).The stay length of the observation group was significantly shorter than that of the control group,and the medication frequency was significantly less than that of the control group(P<0.05).The incidence of allergic reactions and hypoalbuminemia of the observation group were significantly lower than the control group(P<0.05).Conclusion Both L-asparaginase and Pegasparaginase are satisfactory for the short-term prognosis of children with acute lymphoblastic leukemia,and can significantlyimprove the blood routine and blood biochemical indexes,Pegasparaginase can better improve serum LDH,S

关 键 词：急性淋巴细胞白血病 儿童 左旋门冬酰胺酶 培门冬酶 近期疗效 不良反应 乳酸脱氢酶 铁蛋白 血沉 

分 类 号：R733.71[医药卫生—肿瘤]