β-CTX、BAP、uNTx联合检测对于诊断肺癌骨转移的价值  

The Value of Combined Detection ofβ-CTX,BAP and uNTx for the Diagnosis of Bone Metastasis from Lung Cancer

作　　者：杨艳荣 郑先雷 李洪洋 YANG Yanrong;ZHENG Xianlei;LI Hongyang(Shengde Hospital,Xinyang,464000)

机构地区：[1]河南圣德医院,464000

出　　处：《实用癌症杂志》2021年第3期401-403,407,共4页The Practical Journal of Cancer

摘　　要：目的探讨血清β-Ⅰ型胶原羧基端肽(β-CTX)、骨碱性磷酸酶(BAP)、尿Ⅰ型胶原交联氨基末端肽(uNTx)诊断肺癌骨转移的价值。方法选取64例肺癌骨转移患者(转移组)、60例肺癌未发生骨转移的患者(对照组);检测2组的血清β-CTX、BAP、uNTx水平;分析三项指标单独及联合应用时诊断肺癌骨转移的临床价值。结果转移组患者的β-CTX、BAP、uNTx水平均高于对照组,差异具有统计学意义(P<0.05);≥2个转移部位患者的β-CTX、BAP、uNTx水平均高于1个转移部位的患者,差异具有统计学意义(P<0.05)。β-CTX诊断肺癌骨转移的灵敏度为49.21%、特异度为76.42%、AUC值为0.675;BAP诊断肺癌骨转移的灵敏度为57.88%、特异度为79.85%、AUC值为0.738;uNTx诊断肺癌骨转移的灵敏度为68.33%、特异度为81.30%、AUC值为0.758;β-CTX、BAP、uNTx联合应用诊断肺癌骨转移的灵敏度为91.27%、特异度为80.55%、AUC值为0.889。结论β-CTX、BAP、uNTx联合应用诊断肺癌骨转移能显著提高诊断的灵敏度。Objective To investigate the value of serumβ-type Ⅰ collagen carboxy terminal peptide(β-CTX),bone alkaline phosphatase(BAP)and urinary type Ⅰ collagen cross-linked amino terminal peptide(uNTx)in the diagnosis of bone metastases from lung cancer.Methods 64 patients with lung cancer bone metastasis(metastasis group)diagnosed by radionuclide bone scan,and 60 patients with lung cancer without bone metastasis(control group)were selected.The levels of β-CTX,BAP,and uNTx were analyzed.The clinical value of three indicators in the diagnosis of bone metastases from lung cancer was analyzed.Results The levels of β-CTX,BAP and uNTx in the metastatic group were higher than those in the control group(P<0.05).The levels of β-CTX,BAP and uNTx in patients with ≥2 metastatic sites were higher than 1 metastasis.The difference was statistically significant(P<0.05).The sensitivity of β-CTX for the diagnosis of lung cancer bone metastasis was 49.21%,the specificity was 76.42%,and the AUC value was 0.675.The sensitivity of BAP in the diagnosis of lung cancer bone metastasis was 57.88%.The specificity was 79.85%and the AUC value was 0.738.The sensitivity of uNTx for the diagnosis of bone metastasis of lung cancer was 68.33%,the specificity was 81.30%,and the AUC value was 0.758.The sensitivity of β-CTX,BAP and uNTx combined diagnosis of bone metastasis of lung cancer was 91.27%,specificity was 80.55%,and AUC value was 0.889.Conclusion The combined use of β-CTX,BAP,and uNTx to diagnose bone metastasis of lung cancer can significantly improve the sensitivity of diagnosis.

关 键 词：β-Ⅰ型胶原羧基端肽 骨碱性磷酸酶 尿Ⅰ型胶原交联氨基末端肽 肺癌 骨转移 

分 类 号：R734.2[医药卫生—肿瘤]