磷酸铝凝胶联合奥美拉唑治疗消化性溃疡的临床效果  

Clinical effect of aluminium phosphate gel combined with omeprazole on peptic ulcer

作　　者：刘京首 Liu Jingshou(Department of Internal Medicine,Jiaokou Hospital of Traditional Chinese Medicine,Jiaokou 032400,Shanxi Province,China)

机构地区：[1]山西省交口县中医院内科,032400

出　　处：《中国基层医药》2021年第1期35-39,共5页Chinese Journal of Primary Medicine and Pharmacy

基　　金：山西省卫生计生委中医科研计划项目(ZY09)。

摘　　要：目的:观察磷酸铝凝胶联合奥美拉唑治疗消化性溃疡的临床效果。方法:选择交口县中医院2016年1月至2019年10月诊治的消化性溃疡患者48例为研究对象。根据患者入院就诊单双号予以对照研究,其中就诊单号纳入对照组,就诊双号纳入研究组,每组24例。对照组单纯口服奥美拉唑,而研究组口服奥美拉唑的同时口服磷酸铝凝胶。两组疗程4周。观察两组临床疗效、不良反应、胃泌素及转化生长因子α(TGF-α)水平。结果:研究组用药后总体疗效[95.83%(23/24)]高于对照组[79.17%(19/24)](χ^(2)=5.079,P<0.05)。用药前研究组和对照组患者胃泌素[(137.5±18.5)ng/L比(137.1±18.8)ng/L]、TGF-α[(4.3±1.1)μg/L比(4.4±1.2)μg/L]比较均差异无统计学意义(t=0.143、0.156,均P>0.05)。用药后研究组和对照组患者胃泌素下降[(67.6±13.2)ng/L和(85.4±20.3)ng/L(t=18.024、17.569,均P<0.05)]、TGF-α升高[(7.2±1.9)μg/L和(6.1±1.5)μg/L(t=5.268、4.033,均P<0.05)],且研究组改善幅度较对照组更优(t=8.269、9.278,均P<0.05)。研究组不良反应总发生率[12.50%(3/24)]低于对照组[25.00%(6/24)](χ^(2)=6.539,P<0.05)。结论:在奥美拉唑口服的基础之上,对消化性溃疡患者加用磷酸铝凝胶,可进一步提高其临床治疗效果,减轻其症状,改善其血清学指标,且不良反应少,安全可靠。值得在临床中推广。Objective To investigate the clinical effect of aluminium phosphate gel combined with omeprazole on peptic ulcer.Methods Forty-eight patients with peptic ulcer who received treatment in Jiaokou Hospital of Traditional Chinese Medicine from January 2016 to October 2019 were included in this study.They were divided into a control group and a study group according to the registration number at admission.Patients with an odd number were assigned to the control group,and those with an even number to the study group(n=24/group).The control group was treated with oral omeprazole alone,while the study group was treated with oral omeprazole combined with oral aluminium phosphate gel.The course of treatment was 4 weeks in each group.Clinical efficacy,adverse reactions,gastrin and transforming growth factor-αlevels were determined in both groups.Results The overall efficacy in the study group was significantly higher than that in the control group[95.83%(23/24)vs.79.17%(19/24),χ^(2)=5.079,P<0.05].Before treatment,there were no significant differences in gastrin[(137.5±18.5)ng/L vs.(137.1±18.8)ng/L,t=0.143,P>0.05]and transforming growth factor-α[(4.3±1.1)μg/L vs.(4.4±1.2)μg/L,t=0.156,P>0.05]levels between study and control groups.After treatment,gastrin level in the study and control groups decreased[(67.6±13.2)ng/L and(85.4±20.3)ng/L(t=18.024,17.569,both P<0.05)]and transforming growth factor-αin the study and control groups increased[(7.2±1.9)μg/L and(6.1±1.5)μg/L,t=5.268,4.033,both P<0.05)]compared with before treatment.After treatment,the changes in gastrin and transforming growth factor-αlevels relative to before treatment were more obvious in the study group(t=8.269,9.278,both P<0.05)compared with the control group.The total incidence of adverse reactions in the study group was significantly lower than that in the control group[12.50%(3/24)vs.25.00%(6/24),χ^(2)=6.539,P<0.05].Conclusion Based on oral omeprazole,additional oral aluminium phosphate gel for the treatment of peptic ulcer can further improv

关 键 词：消化性溃疡 磷酸铝凝胶 奥美拉唑 治疗结果 安全 胃泌素类 转化生长因子Α 质子泵抑制剂 

分 类 号：R573.1[医药卫生—消化系统]