深共融溶剂中合成2-取代苯并噻唑类化合物  

Synthesis of 2-disubstituted benzothiazole compounds in deep eutectic solvents

作　　者：姜国芳[1] 张灿 陈国庆 王博 谢宗波[1] 乐长高[1] JIANG Guofang;ZHANG Can;CHEN Guoqing;WANG Bo;XIE Zongbo;LE Zhanggao(Jiangxi Province Key Laboratory of Synthetic Chemistry,East China Universily of Technology,Nanchang 330013,Jiangxi,China)

机构地区：[1]东华理工大学江西省合成化学重点实验室,江西南昌330013

出　　处：《精细化工》2021年第1期212-216,共5页Fine Chemicals

基　　金：国家自然科学基金(11765002);江西省科技计划项目(20181BBH80007)。

摘　　要：在由氯化胆碱和乙酰胺组成的深共融溶剂中,以邻氨基苯硫酚和芳香醛为原料,通过环化反应,合成了一系列2-取代苯并噻唑类化合物。当氯化胆碱和乙酰胺的物质的量比为1.0∶2.0时,0.3 mmol邻氨基苯硫酚与0.3 mmol芳香醛在70℃下反应1.0 h,可得到最高产率(经柱色谱分离)为98%的产物。该方法无需其他催化剂,反应条件温和、操作简单、底物范围广泛;深共融溶剂循环使用3次后,产物的产率仍可达到90%以上。A series of 2-disubstituted benzothiazole compounds were synthesized via cyclization coupling of o-aminothiophenols and aromatic aldehydes in deep eutectic solvents.Under the conditions of the deep eutectic solvent made up of choline chloride and acetamide with a molar ratio of 1.0∶2.0,o-aminothiophenol 0.3 mmol,aromatic aldehyde 0.3 mmol,reaction temperature 70℃,and reaction time 1.0 h,the product with the best yield(separated by column chromatography)of 98%was achieved.This synthesis method does not need additional catalyst with mild reaction conditions,simple operations and wide ranges of substrates.In addition,the yield of product could still keep above 90%after the DES was reused for 3 cycles in the model reaction.

关 键 词：深共融溶剂 氯化胆碱-乙酰胺 环化偶联 2-取代苯并噻唑 精细化工中间体 

分 类 号：O625.7[理学—有机化学]