肠黏膜肥大细胞与肠易激综合征发病机制的相关进展  

Relationship between intestinal mucosal mast cells and pathogenesis of irritable bowel syndrome

作　　者：张菊梅 杨杰[1] Zhang Jumei;Yang Jie(Department of Gastroenterology,the First Affiliated Hospital of Guizhou Medical University,Guiyang 550004,china)

机构地区：[1]贵州医科大学第一附属医院消化内科,贵州贵阳550004

出　　处：《医药前沿》2020年第32期7-8,共2页Journal of Frontiers of Medicine

摘　　要：肠易激综合征(irritable bowel syndrome,IBS)属于一种肠功能紊乱综合征,患者经过生化指标检测之后未发现任何异常情况,目前尚无法全面了解该病的具体发病机制,认为与精神心理压力、以往肠道感染、食物过敏以及消化道运动之间存在联系,但尚未定论。而在对患者进行深入研究发现肠黏膜肥大细胞(mast cell,MC)与IBS之间存在非常密切的联系,不同部位肠粘膜的MC变化情况不同可能引起不同类型的疾病,因此需要对肠黏膜肥大细胞与肠易激综合征发病机制作用进行分析,研究相互之间的关系,为临床疾病判断提供更加理想的条件。Irritable bowel syndrome(IBS)is a kind of intestinal dysfunction syndrome.No abnormality was found in the patients after biochemical tests.At present,the specific pathogenesis of IBS can not be fully understood.It is believed that there is a relationship between IBS and mental stress,previous intestinal infection,food allergy and gastrointestinal movement,but it has not been concluded.However,in-depth study of patients,mast cells(MAST)were found in intestinal mucosa There is a very close relationship between IBS and MC in different parts of intestinal mucosa,which may cause different types of diseases.Therefore,it is necessary to analyze the role of intestinal mucosal mast cells and the pathogenesis of irritable bowel syndrome,and study the relationship between them,so as to provide more ideal conditions for clinical disease judgment.

关 键 词：肠黏膜肥大细胞 肠易激综合征 发病机制 P物质 组胺 

分 类 号：R574[医药卫生—消化系统]