PD-1/PD-L1在病毒类畜禽免疫抑制疾病中的研究进展  

Research on PD-1/PD-L1 in livestock and poultry immunosuppressive diseases

作　　者：陈威 孙国鹏[1] 何海汛 李丹 蒋力维 王选年[1] CHEN Wei;SUN Guopeng;HE Haixun;LI Dan;JIANG Liwei;WANG Xuannian(Biotechnology Research Center,Xinxiang University,Xinxiang 453003,China;College of Life Sciences,Zhengzhou University,Zhengzhou 450001,China)

机构地区：[1]新乡学院生物技术研究中心,河南新乡453003 [2]郑州大学生命科学学院,郑州450001

出　　处：《黑龙江畜牧兽医》2021年第1期28-32,35,共6页Heilongjiang Animal Science And veterinary Medicine

基　　金：国家自然科学基金项目“阻断PD-1/PD-L1通路对鸡传染性法氏囊病引发的T细胞免疫抑制的恢复作用”(31272539);国家自然科学基金项目“干扰素相关STATs信号通路对鸡PD-1及PD-L1转录的调节作用”(3167131497);新乡学院青年骨干教师项目(1244160006)。

摘　　要：程序性死亡因子-1(programmed death-1,PD-1或CD279)是一种免疫抑制受体,其与配体PD-L1通过相互作用介导PD-1/PD-L1信号通路的激活,可导致T细胞免疫功能耗竭,表现为免疫调节相关细胞因子的表达异常、效应T细胞增殖、分化能力降低等,进而对机体免疫功能发挥负向调节作用。文章基于畜禽免疫抑制类疾病相关领域内的现有研究结果,分别对PD-1/PD-Ls在疾病不同阶段的表达、分布、表达模式以及二者的异常表达对T淋巴细胞增殖、效应细胞分化和免疫调节相关细胞因子的分泌等细胞免疫抑制效应影响等方面进行总结,探讨并分析PD-1/PD-Ls通路与畜禽免疫抑制类疾病发生、发展的关系和相关的分子机制,以期为进一步研究畜禽免疫抑制类疾病致病机制等提供参考,也为开发以PD-1/PD-L1为靶点的治疗和预防畜禽免疫抑制疾病的新型药物或疫苗提供理论基础和依据。Programmed death-1(PD-1 or CD279) is an immunosuppressive receptor. PD-1 can be activated by PD-1/PD-L1 signal pathway mediated by interaction with its corresponding ligand PD-L1, which can lead to the depletion of T cell immune function, such as the aberrant expression of immune-regulating cytokines, decreased proliferation and differentiation abilities of effector T cells, and subsequently exert negative regulation on immune functions of the body. Our study, based on existing research on immunosuppressive diseases in livestock and poultry, summarized the PD-1/PD-L1 expression distribution and pattern at different stages of disease and the immunosuppression effects on T cell proliferation, differentiation and secretion of immune-regulating cytokines driven by PD-1/PD-L1 abnormal expression. Further, we explored and analyzed the relationships and relevant molecular mechanisms between the PD-1/PD-L1 pathway and the development of immunosuppressive diseases in livestock and poultry. Our study provides relevant reference for further research of the pathogenic mechanism of immunosuppressive diseases in livestock and poultry, and theoretical basis for the development of new drugs or vaccines targeting PD-1/PD-L1 for the treatment and prevention of immunosuppressive diseases in livestock and poultry.

关 键 词：PD-1 PD-L1 免疫抑制 畜禽疾病 免疫功能 

分 类 号：S852.4[农业科学—基础兽医学]