缺氧诱导因子-1与恶性肿瘤关系的研究进展  

Research Progress in Relationship between Hypoxia-inducible Factor-1 and Malignant Tumors

作　　者：张璐[1] 方岳 牛继国[3] 陈彻[1] 李海龙[1] 王功臣 张学良[4] 梁艳 呼永华[1,5] 张志明 ZHANG Lu;FANG Yue;NIU Jiguo;CHEN Che;LI Hailong;WANG Gongchen;ZHANG Xueliang;LIANG Yan;HU Yonghua;ZHANG Zhiming(The First Clinical Medical College,Gansu University of Chinese Medicine,Lanzhou 730000,China;Procurement Office,Gansu Provincial Hospital of Traditional Chinese Medicine,Lanzhou 730050,China;Department of Nuclear Medicine,Gansu Provincial Cancer Hospital,Lanzhou 730050,China;Internal Medicine Department 1 of Digestive Cancer,Gansu Provincial Cancer Hospital,Lanzhou 730050,China;Department of Oncology,Affiliated Hospital of Gansu University of Chinese Medicine,Lanzhou 730000,China)

机构地区：[1]甘肃中医药大学第一临床医学院,兰州730000 [2]甘肃省中医院采购办,兰州730050 [3]甘肃省肿瘤医院核医学科,兰州730050 [4]甘肃省肿瘤医院消化肿瘤内一科,兰州730050 [5]甘肃中医药大学附属医院肿瘤科,兰州730000

出　　处：《医学综述》2021年第5期924-930,共7页Medical Recapitulate

基　　金：甘肃省中西医结合肿瘤临床医学研究中心建设项目(18JR2FA001);甘肃省自然科学基金(17JR5RA169);甘肃省高等学校科研项目(2016A-045);甘肃中医药大学科学研究与创新基金(2019KC2D-1)。

摘　　要：低氧是恶性肿瘤微环境的特征之一,缺氧诱导因子-1(HIF-1)是细胞适应低氧环境的重要调节因子。HIF-1是低氧环境下的氧调节型α亚基与组成型β亚基形成的稳定的异二聚体,其促进肿瘤血管生成、上调并激活基质金属蛋白酶及赖氨酸氧化酶等细胞因子及信号通路、诱导特异性微RNA生成,参与多种恶性肿瘤细胞的增殖、侵袭、转移等相关生物学行为。通过不同的方式抑制HIF-1α的活性,改变其结构稳定性,对于恶性肿瘤的治疗具有重要意义。但HIF-1α能否成为恶性肿瘤治疗的靶点及其预后判断的指标,有待于进一步的研究探索。Hypoxia is one of the characteristics of the malignant tumor microenvironment.Hypoxia-inducible factor-1(HIF-1)is an important regulator of cells adapting to the hypoxic environment.HIF-1 is a stable heterodimer formed by oxygen-regulatedαsubunit with constitutiveβsubunit under hypoxic environment.It promotes tumor angiogenesis,upregulates and activates matrix metalloproteinases and lysine oxidase and other cytokines and signal pathways,induces specific miRNA production,and participates in the biological behaviors of proliferation,invasion and metastasis of various malignant tumor cells.Inhibiting the activity of HIF-1αin different ways and changing its structural stability are of great significance for the treatment of malignant tumors.However,whether HIF-1αcan become a target of malignant tumor treatment and its prognostic index needs to be further studied and explored.

关 键 词：恶性肿瘤 缺氧诱导因子-1 缺氧诱导因子-1α抑制剂 

分 类 号：R730.2[医药卫生—肿瘤]