地黄饮子加减对急性脑梗死患者血小板聚集率及VEGF的影响  

Effects of ModifiedDihuang Yingzi on Platelet Aggregation Rate and VEGF in the Patients with Acute Cerebral Infarction

作　　者：秦保锋[1] 王明哲[1] 龚帆[1] 王骏[1] 张红智[1] 郭咏梅[1] QIN Baofeng;WANG Mingzhe;GONG Fan;WANG Jun;ZHANG Hongzhi;GUO Yongmei(Department of Neurology,Shuguang Hospital Affiliated to Shanghai University of TCM,Shanghai 201203,China)

机构地区：[1]上海中医药大学附属曙光医院神经内科,上海201203

出　　处：《西部中医药》2021年第1期95-98,共4页Western Journal of Traditional Chinese Medicine

基　　金：第六批全国老中医药专家学术经验继承项目(国中药人教发〔2017〕29号);上海中医药大学预算内项目(2016YSN46)。

摘　　要：目的:探讨地黄饮子加减对急性脑梗死患者血小板聚集率、血管内皮生长因子(vascular endothelial growth factor,VEGF)的影响。方法:将急性脑梗死患者120例随机分为治疗组与对照组各60例,对照组予常规疗法,治疗组在对照组基础上予地黄饮子加减治疗,治疗14天后观察两组患者神经功能缺损、血小板聚集率与VEGF变化情况及安全性。结果:与治疗前比较,两组患者治疗后神经功能缺损积分减少,血小板聚集率下降,差异均有统计学意义(P<0.05);VEGF水平升高,对照组治疗前后比较差异无统计学意义(P>0.05),治疗组治疗前后比较差异有统计学意义(P<0.05);治疗组神经功能缺损、血小板聚集率及VEGF水平改善优于对照组,差异有统计学意义(P<0.05),且无明显副作用。结论:常规治疗联合地黄饮子加减可能通过调节血小板聚集功能、VEGF表达改善急脑梗死患者神经功能。Objective:To study the effects of modified Dihuang Yinzi on platelet aggregation rate and vascular endothelial growth factor(VEGF)in patients with acute cerebral infarction(ACI).Methods:All 120 ACI patients were randomly divided into the treatment group and the control group,60 cases each group,the control group were treated by conventional therapy,and the treatment group took modified Dihuang Yinzi based on conventional therapy,to observe the changes of NIHSS,platelet aggregation rate and VEGF,and the safety in both groups 14 days after treating.Results:After treating,NIHSS scores reduced and platelet aggregation rate lowered in both groups after treating,the difference had statistical meaning compared with before treating(P<0.05),VEGF levels rose,and the difference had no statistical meaning in the control group before and after treating(P>0.05),the difference was statistically significant in the treatment group before and after treating(P<0.05);the treatment group was superior to the control group in the improvements of NIHSS,platelet aggregation rate and VEGF,and there was a significant difference(P<0.05),no obvious side effects.Conclusion:Modified Dihuang Yinzi combined with conventional therapy could improve neurological function which might be through regulating platelet aggregation and the expressions of VEGF.

关 键 词：急性脑梗死 血小板聚集率 血管内皮生长因子 地黄饮子 临床疗效 

分 类 号：R742[医药卫生—神经病学与精神病学]