糖酵解关键酶在宫颈癌 Warburg效应中的作用研究进展  

Research progression of the infection of glycolytic enzymein the Warburg effect in cervical cancer

作　　者：范佳杨 梁婷(综述) 刘康 罗岳西(审校)[1] FAN Jia-yang;LIANG Ting;LIU Kang;LUO Yue-xi(Department of Obstetrics and Gynecology,Nanchong Central Hospital,The Second Clinical Medical College,North Sichuan Medical College,Nanchong 637000,Sichuan,China;Department of Tissue Engineering and Stem Cell Institute,Nanchong Central Hospital,Nanchong 637000,Sichuan,China)

机构地区：[1]川北医学院第二临床医学院(南充市中心医院)妇产科,南充637000 [2]南充市中心医院组织工程与干细胞研究所,南充637000

出　　处：《东南国防医药》2021年第2期175-179,共5页Military Medical Journal of Southeast China

基　　金：四川省教育厅项目(16ZA0239);南充市校科技战略合作项目(18SXHZ0361)。

摘　　要：宫颈癌是女性最常见的恶性肿瘤之一,其发病率在全球范围内仅次于乳腺癌,死亡率位居全球第二。全世界每年约有50万名妇女被诊断出宫颈癌,有25万名妇女死于宫颈癌。Warburg效应存在于大部分肿瘤细胞中,是肿瘤细胞的代谢特征之一,又称为有氧糖酵解,是指在癌变时,无论是否缺氧,肿瘤细胞都更倾向于糖酵解的代谢途径,而非靠更有效的氧化磷酸化来产生能量。文章主要就醇化酶、磷酸甘油酸变位酶、己糖激酶、丙酮酸激酶、乳酸脱氢酶等在宫颈癌组织中表达异常,且在宫颈癌的发生发展过程中起重要作用的关键酶进行综述。Cervical cancer is among the most common malignant tumors in women.Its incidence is second only to breast cancer in the world,and its mortality ranks second in the world.Around half a million women worldwide are diagnosed with cervical cancer each year and 250000 women die from it.Warburg effect exists in most tumor cells and is part of the metabolic characteristics of tumor cells.Also known as aerobic glycolysis,it means that tumor cells prefer the metabolic pathway of glycolysis to generate energy by more effective oxidative phosphorylation regardless of hypoxia during cancerization.In this paper,Enolase,phosphoglycerate mutase(PGAM),Hexokinase(HK),pyruvate kinase(PK),lactate dehydrogenase(LDH)and other key enzymes that are abnormally expressed in cervical cancer tissues and play an important role in the occurrence and development of cervical cancer are reviewed.To explore biomarkers that can be used as diagnostic predictors of prognosis,or effective targets for gene therapy.

关 键 词：宫颈癌 Warburg效应 糖酵解 

分 类 号：R73[医药卫生—肿瘤]