导痰汤治疗痰浊上扰型急性脑梗死的临床研究  

Clinical Research of Daotan Decoction in the Treatment of Acute Cerebral Infarction with Phlegm-turbidity Disturbing Mind

作　　者：陈玉静[1] 黄小波[1] 刘妍[1] 王倩[1] 孙亚男[1] 吴犀翎[1] 王建东[1] CHEN Yujing;HUANG Xiaobo;LIU Yan;WANG Qian;SUN Ya′nan;Wu Xiling;WANG Jiandong(Xuanwu Hospital Capital Medical University,Beijing 100053,China)

机构地区：[1]首都医科大学宣武医院,北京100053

出　　处：《中西医结合心脑血管病杂志》2021年第4期561-564,共4页Chinese Journal of Integrative Medicine on Cardio-Cerebrovascular Disease

基　　金：北京市中医药科技项目(No.JJ2018-22);北京市自然科学基金(No.7162079,7172094)。

摘　　要：目的观察导痰汤治疗痰浊上扰型急性脑梗死的临床疗效及对血管内皮功能的影响。方法选取轻中度急性脑梗死病人86例,采用随机数字表法分为对照组和导痰汤组,各43例。对照组给予常规治疗,导痰汤组在对照组治疗基础上加服中药导痰汤。治疗7 d后及14 d后,采用美国国立卫生研究院卒中量表(NIHSS)评价病人神经功能缺损程度,比较两组临床疗效及血管内皮功能因子[包括内皮祖细胞(EPCs)、血管内皮生长因子(VEGF)、细胞间黏附因子-1(ICAM-1)、一氧化氮(NO)和内皮素(ET)-1]表达情况。结果导痰汤组总有效率为95.34%高于对照组的81.39%(P<0.01)。与治疗前比较,治疗后两组NIHSS评分均降低(P<0.01),且治疗7 d后、14 d后导痰汤组NIHSS评分均低于对照组(P<0.01)。治疗7 d后、14 d后,导痰汤组EPCs、VEGF和NO表达高于对照组,ET-1和ICAM-1表达较对照组下降,差异均有统计学意义(P<0.05或P<0.01)。结论导痰汤可提高痰浊上扰型急性脑梗死病人EPCs数量,改善血管内皮功能,促进神经功能恢复。Objective To observe the clinical efficacy of Daotan Decoction in the treatment of acute cerebral infarction with phlegm-turbidity disturbing mind and its effect on vascular endothelial function.Methods Eighty-six patients with acute cerebral infarction were randomly divided into the control group and Daotan Decoction group,43 cases in each group.The control group was treated with conventional therapy,and the Daotan Decoction group was treated with Daotan Decoction on the basis of the control group.After 7 days and 14 days,the clinical efficacy,National Institutes of Health Stroke Scale(NIHSS),and the expression of cytokine related to vascular endothelial function[endothelial progenitor cells(EPCs),vascular endothelial growth factors(VEGF),intercellular adhesion factor-1(ICAM-1),nitric oxide(NO)and endothelin-1(ET-1)]were compared between two groups.Results The clinical efficacy of Daotan Decoction group was significantly higher than that of the control group(95.34%vs 81.39%,P<0.01).Compared with those before treatment,NIHSS scores in both groups decreased after treatment(P<0.01),and NIHSS score in Daotan Decoction group was lower than that in control group(P<0.01).After treatment,the levels of EPCs,VEGF,and NO in Daotan Decoction group were higher than those in the control group,and the levels of ET-1 and ICAM-1 in Daotan Decoction group were lower than those in the control group(P<0.05 or P<0.01).Conclusion Daotan Decoction in the treatment of acute cerebral infarction with phlegm-turbidity disturbing mind could obviously increase the number of EPCs,improve the endothelial function,and promote the recovery of nerve function.

关 键 词：急性脑梗死 痰浊上扰型 导痰汤 内皮祖细胞 血管内皮功能 

分 类 号：R74[医药卫生—神经病学与精神病学]