术前SCC-Ag对早期宫颈鳞癌盆腔淋巴结转移预测价值研究  

Predictive value of pretreatment serum SCC-Ag for pelvic lymph node metastasis in early cervical squamous cancer

作　　者：李兰[1] 徐凡[2] 胡辉权[2] 王敏[1] 林单 LI Lan;XU Fan;HU Huiquan;WANG Min;LIN Dan(Affiliated Hospital of North Sichuan Medical College,Nanchong Sichuan 637000,China)

机构地区：[1]川北医学院附属医院妇产科,四川南充637000 [2]川北医学院附属南充市中心医院妇产科 [3]川北医学院

出　　处：《中国妇产科临床杂志》2021年第1期3-5,共3页Chinese Journal of Clinical Obstetrics and Gynecology

基　　金：四川省教育厅项目(SWFZ17-Y-25);四川省教育厅项目(SWFZ17-C-69);南充市科技与知识产权项目(16YFZJ0029);南充市社科联项目(NC2016B017)。

摘　　要：目的探索鳞状细胞癌抗原(SCC-Ag)对宫颈鳞癌盆腔淋巴结转移的预测价值。方法回顾性分析2007年1月至2017年1月于南充市中心医院接受初始治疗为根治性手术的603例早期宫颈鳞癌患者。统计学比较其临床病理特征,并采用Logistic回归分析影响盆腔淋巴结转移的危险因素,绘制ROC曲线确定SCCAg预测盆腔淋巴结转移的最佳临界水平。结果603例早期宫颈鳞癌患者中有淋巴结转移组(113例),无淋巴结转移组(490例)。单因素及多因素分析提示宫旁转移(OR=3.561)、脉管浸润(OR=6.846)和SCC-Ag(OR=8.426)是预测宫颈鳞癌淋巴结转移的独立危险因素。SCC-Ag预测宫颈鳞癌淋巴结转移的最佳临界值为1.7 ng/ml。结论术前SCC-Ag>1.7 ng/ml为宫颈鳞癌盆腔淋巴结转移的独立危险因素。Objective To analyze the predictive value of squamous cell carcinoma antigen(SCC-Ag)for pelvic lymph node metastasis in early cervical squamous carcinoma.Methods A retrospective analysis of 603 early cervical squamous cell carcinoma patients who underwent radical surgery as initial treatment at Nanchong Central Hospital from January 2007 to January 2017 was implemented.The clinicopathological characteristics were statistically compared,and the risk factors affecting pelvic lymph node metastasis were analyzed by logistic regression.The ROC curve was drawn to determine the optimal critical level of SCC-Ag for predicting pelvic lymph node metastasis.Results The 603 cases were categorized into lymph node metastasis group(113 cases)and no lymph node metastasis group(490 cases).The univariate and multivariate logistic analysis results showed the independent risk factors of lymph node metastasis including parametrial spread(OR=3.561),vascular invasion(OR=6.846)and serum SCC-Ag level(OR=8.426).The optimal threshold for SCC-Ag to predict lymph node metastasis of cervical squamous cell carcinoma was 1.7 ng/ml.Conclusion Preoperative SCC-Ag>1.7 ng/ml is independent risk factors for pelvic lymph node metastasis of cervical cancer.

关 键 词：宫颈鳞癌 盆腔淋巴结转移 鳞状细胞癌抗原 

分 类 号：R737.33[医药卫生—肿瘤]