左半结肠癌临床病理与分子特征的相关性研究  

Relationship between clinicopathological and molecular characteristics of left colon cancer

作　　者：张嘎 杨学超 ZHANG Ga;YANG Xue-chao(Department of General Surgery,Zizhou County People's Hospital,Yulin 718499,China;pepartment of Pathology,NO.215 Hospital of Shaanxi Nuclear Industry,Xianyang 712000,China)

机构地区：[1]陕西省榆林市子洲县人民医院普外科,榆林718499 [2]陕西省核工业二一五医院病理科,咸阳712000

出　　处：《中国肿瘤临床与康复》2020年第12期1444-1447,共4页Chinese Journal of Clinical Oncology and Rehabilitation

摘　　要：目的探讨左半结肠癌临床病理特征与分子特征的相关性。方法选取2015年8月至2019年12月于陕西省榆林市子洲县中医院收治的行手术切除的78例左半结肠癌患者的肿瘤组织标本为病灶组,另取癌旁组织标本(距肿瘤边缘≥5cm正常结直黏膜)作为癌旁组,检测两组组织中分子特征标记物MiR-21表达情况,调查患者的临床病理特征并进行相关性分析。结果病灶组的MiR-21相对表达水平高于癌旁组,差异有统计学意义(P<0.05)。不同年龄、性别和病理类型左半结肠癌患者的肿瘤组织中的MiR-21表达水平比较,无明显差异(P>0.05),而不同肿瘤直径、组织学分化、浆膜浸润和临床分期左半结肠癌患者的肿瘤组织中的MiR-21表达水平比较,差异均有统计学意义(均P<0.05)。经Logistic分析得出,患者MiR-21相对表达水平的独立危险因素为浆膜浸润、肿瘤直径和临床分期(均P<0.05)。结论左半结肠癌患者组织中MiR-21表达上调,与患者的临床病理特征(肿瘤直径、浆膜浸润、组织学分化和临床分期)相关。Objective To explore the relationship between clinicopathological and molecular features of left colon cancer.Methods From August 2015 to December 2019,specimens from 78 patients with left colon cancer patients(lesion group)and paracancerous tissue specimens(paracancerous group,≥5 cm away from the tumor edge margin)were selected.The expression of MiR-21,a molecular feature marker was detected in the two groups.The clinicopathological characteristics were investigated and the relationship was analyzed.Results The relative expression level of MiR-21 were significantly higher in the lesion group than in the paracancerous group(P<0.05).There were no statistically significant difference in MiR-21 expression levels in patients with left half colon cancer of different ages,genders and pathological types(P>0.05),and there were statistically significant difference in the expression level of MiR-21 in patients with left colon cancer of different clinical stages,tumor diameters,serosal infiltration,and histological differentiation(all P<0.05).Logistic analysis showed that clinical stage,tumor diameter and serosal invasion were independent factors influencing the relative expression level of MiR-21(all P<0.05).Conclusion MiR-21 was highly expressed in the tissues in patients with left colon cancer and the expression of MiR-21 was associated with the clinicopathological features of patients with left colon cancer including clinical stage,tumor diameter,serosal infiltration and histological differentiation.

关 键 词：左半结肠肿瘤 MIR-21 临床分期 浆膜浸润 分子特征 

分 类 号：R735.3[医药卫生—肿瘤]