艾迪注射液辅助化疗治疗妇科恶性肿瘤临床研究  

Clinical Study on AD Injection in Adjuvant Chemotherapy of Gynecologic Malignant Tumor

作　　者：杨超群 朱伟珍[1] 蔡飞霞[1] YANG Chaoqun;ZHU Weizhen;CAI Feixia

机构地区：[1]丽水市中心医院肿瘤内科,浙江丽水323000

出　　处：《新中医》2021年第4期143-146,共4页New Chinese Medicine

摘　　要：目的:观察艾迪注射液辅助化疗治疗妇科恶性肿瘤的临床疗效。方法:将108例妇科恶性肿瘤患者按随机数字表法分为观察组和对照组各54例。对照组采用常规化疗治疗,观察组在对照组基础上给予艾迪注射液疗治疗。比较2组治疗前后T淋巴细胞亚群CD4^(+)、CD4^(+)/CD8^(+)、CD3^(+)、CD8^(+)、自然杀伤(NK)细胞水平,检测干扰素-γ(IFN-γ)、白细胞介素-2(IL-2)、白细胞介素-4(IL-4)、白细胞介素-10(IL-10)、白细胞介素-6(IL-6)、人附睾蛋白4(HE4)、泌乳素(PRL)、血清恶性肿瘤特异性生长因子(TSGF)的变化情况。结果:治疗前,2组CD4^(+)、CD4^(+)/CD8^(+)、CD3^(+)、CD8^(+)、NK细胞比较,差异均无统计学意义(P>0.05)。治疗后,2组CD4^(+)、CD4^(+)/CD8^(+)、CD3^(+)较治疗前降低,CD8^(+)、NK细胞较治疗前升高;但观察组CD4^(+)、CD4^(+)/CD8^(+)、CD3^(+)高于对照组,CD8^(+)、NK细胞低于对照组;差异均有统计学意义(P<0.05)。治疗前,2组血清IFN-γ、IL-2、IL-4、IL-10、IL-6、HE4、PRL、TSGF水平比较,差异均无统计学意义(P>0.05)。治疗后,2组IFN-γ、IL-2水平较治疗前升高,IL-4、IL-10、IL-6、HE4、PRL、TSGF水平较治疗前降低;且观察组IFN-γ、IL-2水平高于对照组,IL-4、IL-10、IL-6、HE4、PRL、TSGF水平低于对照组;差异均有统计学意义(P<0.05)。结论:艾迪注射液辅助化疗治疗妇科恶性肿瘤患者临床疗效显著,能有效改善细胞免疫功能,减轻细胞炎性因子水平。Objective:To observe the clinical effect of AD injection in adjuvant chemotherapy of gynecologic malignant tumor.Methods:A total of 108 cases of patients with gynecologic malignant tumor were divided into the observation group and the control group according to the random number table method,54 cases in each group.The control group was treated with routine chemotherapy,and the observation group was additionally treated with AD injection based on the treatment of the control group.Before and after treatment,the levels of T lymphocyte subsets CD4^(+),CD4^(+)/CD8^(+),CD3^(+)and CD8^(+),and natural killer(NK)were compared between the two groups.The changes in interferon-γ(IFN-γ),interleukin-2(IL-2),interleukin-4(IL-4),interleukin-10(IL-10),interleukin-6(IL-6),human epididymal protein 4(HE4),prolactin(PRL)and tumor specific growth factor(TSGF)in serum were measured.Results:Before treatment,when compared the levels of CD4^(+),CD4^(+)/CD8^(+),CD3^(+),CD8^(+)and NK between the two groups,there was no significance in differences(P>0.05).After treatment,the levels of CD4^(+),CD4^(+)/CD8^(+),and CD3^(+)in the two groups were decreased when compared with those before treatment,and the levels of CD8^(+)and NK were increased;the levels of CD4^(+),CD4^(+)/CD8^(+),and CD3^(+)in the observation group were higher than those in the control group,and the levels of CD8^(+)and NK were lower;differences were significant(P<0.05).Before treatment,when compared the levels of IFN-γ,IL-2,IL-4,IL-10,IL-6,HE4,PRL,and TSGF in serum between the two groups,there was no significance in differences(P>0.05).After treatment,the levels of IFN-γand IL-2 in the two groups were increased when compared with those before treatment,and the levels of IL-4,IL-10,IL-6,HE4,PRL and TSGF were decreased;the levels of IFN-γand IL-2 in the observation group were higher than those in the control group,and the levels of IL-4,IL-10,IL-6,HE4,PRL and TSGF were lower;differences were significant(P<0.05).Conclusion:AD injection in adjuvant chemotherapy of gynecologic

关 键 词：妇科恶性肿瘤 艾迪注射液 化疗 T淋巴细胞亚群 炎症因子 

分 类 号：R737.3[医药卫生—肿瘤]