祛风止痒汤联合西药治疗肝硬化黄疸伴皮肤瘙痒临床研究  

Clinical Study on Qufeng Zhiyang Tang Combined with Western Medicine for Liver Cirrhosis Complicated with Jaundice Concomitant with Pruritus

作　　者：吴雯莉 王进[2] WU Wenli;WANG Jin

机构地区：[1]杭州市第三人民医院,浙江杭州310009 [2]杭州师范大学附属医院,浙江杭州310015

出　　处：《新中医》2021年第2期194-197,共4页New Chinese Medicine

摘　　要：目的:观察祛风止痒汤联合西药治疗肝硬化黄疸伴皮肤瘙痒患者临床效果。方法:选取肝硬化黄疸伴皮肤瘙痒患者113例,按随机数字表法分为对照组53例,治疗组60例。对照组予以复方甘草酸苷片联合他克莫司治疗,治疗组在对照组的基础上联合祛风止痒汤治疗。比较2组治疗前后症状评分(瘙痒程度、发作频率、持续时间、瘙痒面积、睡眠质量、自觉病情程度、皮肤干燥程度、继发皮损);观察2组临床疗效、不良反应发生情况(红肿、刺痛、灼烧感)及复发情况。结果:治疗组总有效率为93.33%,对照组为79.25%,2组比较,差异有统计学意义(P<0.05)。治疗后,2组瘙痒程度、发作次数、持续时间、瘙痒面积、睡眠质量、自觉症状、皮肤干燥、继发皮损等症状评分均较治疗前降低(P<0.05),且治疗组各项评分低于对照组(P<0.05)。随访12个月,治疗组皮肤症状复发率为5.36%,对照组为21.43%,2组比较,差异有统计学意义(P<0.05)。治疗组不良反应发生率为11.67%,对照组为13.21%,2组比较,差异无统计学意义(P>0.05)。结论:祛风止痒汤联合西药治疗肝硬化黄疸伴皮肤瘙痒效果显著,可改善患者临床症状,且复发率低。Objective:To observe the clinical effect of Qufeng Zhiyang tang combined with western medicine for the liver cirrhosis complicated with jaundice concomitant with pruritus. Methods:A total of 113 cases of patients with the liver cirrhosis complicated with jaundice concomitant with pruritus were selected and divided into the control group and the treatment group according to the random number table method, 53 and 60 cases in each group respectively. The control group was given compound glycyrrhizin tablets combined with tacrolimus, and the treatment group was additionally given Qufeng Zhiyang tang based on the treatment of the control group. The syndrome scores were compared between the two groups before and after treatment, which included pruritus degree, seizure frequency, duration, pruritus area, sleep quality,degree of conscious attention on condition,degree of dry skin,and secondary lesion. The clinical effect,as well as the incidence and recurrence of adverse reactions including redness and swelling,stabbing pain,and burning sensation were observed in the two groups. Results:The total effective rate was 93.33% in the treatment group,and 79.25% in the control group, the difference being significant(P<0.05). After treatment, the syndrome scores of pruritus degree, seizure frequency,duration,pruritus area,sleep quality,subjective symptoms,dry skin,and secondary lesion were decreased when compared with those before treatment(P<0.05),and each syndrome score in the treatment group was lower than that in the control group(P<0.05). After 12 months of follow-up,the recurrence rate was 5.36% in the treatment group,and21.43% in the control group,the difference being significant(P<0.05). The incidence of adverse reactions was 11.67% in the treatment group,and 13.21% in the control group,and there was no significant difference being found in the comparison of the incidence between the two groups(P>0.05). Conclusion:In the treatment of patients with the liver cirrhosis complicated with jaundice concomitant with pruritus,th

关 键 词：肝硬化 黄疸伴皮肤瘙痒 复方甘草酸苷片 他克莫司 祛风止痒汤 

分 类 号：R575.2[医药卫生—消化系统]