不同ER PR阳性表达/HER2阴性乳腺癌的临床病理特征  

Clinicopathological characteristics of HER2 negative breast cancer patients of different positive expression of ER or PR

作　　者：陆建菊 郭文利 陈彩萍 陆翔 黄建棋 陆凯 LU Jian-Ju;GUO Wen-Li;CHEN Cai-Ping(Department of Mastopathy,the First Hospital of Jiaxing,Jiaxing,Zhejiang 314000,China)

机构地区：[1]嘉兴市第一医院乳腺病科,浙江嘉兴314000

出　　处：《中国妇幼保健》2021年第5期1156-1159,共4页Maternal and Child Health Care of China

基　　金：嘉兴市科技计划项目(2019AD32062)。

摘　　要：目的探讨不同ER、PR阳性表达/HER2阴性乳腺癌的临床病理特征。方法回顾性分析2003-2014年ER或PR不同程度阳性表达且HER2阴性浸润性乳腺癌的临床病理资料,其中ER+PR+HER2-乳腺癌362例,ER+PR-HER2-乳腺癌36例,ER-PR+HER2-乳腺癌49例。结果ER+PR-HER2-乳腺癌相比较于ER+PR+HER2-乳腺癌更趋向于高龄以及绝经后患者,ER-PR+HER2-相比较于及ER+PR-HER2-乳腺癌更趋向于年轻患者,而ER+PR-HER2-相比较于ER-PR+HER2-乳腺癌TNM分期更高,差异均有统计学意义(P<0.05)。三者在肿瘤的部位、Ki-67高低及淋巴结转移方面差异无统计学意义(P>0.05),不同ER、PR阳性表达/HER2阴性乳腺癌在DFS及OS上差异无统计学意义(P>0.05)。结论在HER2-乳腺癌中,PR的阳性表达更趋向于年轻患者,而ER阳性时PR表达的缺失显示出更高的TNM分期,提示PR在乳腺癌发生发展中的潜在意义,但尚需要进一步大样本的研究来探索其对于乳腺癌生存的影响,从而进一步丰富乳腺癌个体化治疗。Objective To explore the clinicopathological characteristics of HER2 negative breast cancer patients of different positive expression of ER or PR.Methods The clinicopathological data of HER2 negative breast cancer patients of different positive expression of ER or PR from 2003 to 2014 were analyzed retrospectively,362 cases with positive ER,positive PR,negative HER2 breast cancer,36 cases with positive ER,negative PR,negative HER2 breast cancer,and 49 cases with negative ER,positive PR,negative HER2 breast cancer were included.Results Compared with the patients with positive ER,positive PR,negative HER2 breast cancer,positive ER,negative PR,negative HER2 breast cancer was mainly observed in elderly patients and postmenopausal patients;compared with the patients with positive ER,negative PR,negative HER2 breast cancer,negative ER,positive PR,negative HER2 breast cancer was mainly observed in young patients;compared with the patients with negative ER,positive PR,negative HER2 breast cancer,TNM stage in positive ER,negative PR,negative HER2 breast cancer patients was higher(P<0.05).There was no statistically significant difference in tumor site,Ki-67 level,and lymph node metastasis among the three groups(P>0.05).There was no statistically significant difference in DFS and OS among HER2 negative breast cancer patients of different positive expression of ER or PR(P>0.05).Conclusion Among HER2 negative breast cancer patients,positive PR is mainly observed in young patients,positive ER and negative PR indicate high TNM stage,which illustrates the potential significance of PR in occurrence and development of breast cancer,but further studies based on large sample are needed to explore the impact on survival of breast cancer patients and further enrich individualized treatment of breast cancer.

关 键 词：乳腺癌 ER表达 PR表达 HER2阴性 

分 类 号：R737.9[医药卫生—肿瘤]