安络化纤丸联合西药治疗乙肝肝硬化患者的临床疗效  

Clinical Efficacy of Anluo Huaxian Pills Combined with Western Medicine in the Treatment of Hepatitis B Cirrhosis

作　　者：于成文[1] 孟晨鑫 王岩[1] 潘良宇[1] YU Cheng-Wen;MENG Chen-Xin;WANG Yan;PAN Liang-Yu(The Second Department of Hepatology,the Sixth People's Hospital of Shenyang,Shenyang 110006,China)

机构地区：[1]沈阳市第六人民医院肝病二科,沈阳110006

出　　处：《中国药物经济学》2020年第12期57-61,共5页China Journal of Pharmaceutical Economics

摘　　要：目的探讨安络化纤丸联合水飞蓟治疗乙肝肝硬化患者的临床疗效。方法选取2018年6月至2019年11月于沈阳市第六人民医院治疗的80例乙肝肝硬化患者作为研究对象,采用随机数字表法分为对照组与观察组,各40例。对照组采用抗病毒联合保肝治疗,观察组在对照组治疗基础上加用安络化纤丸治疗,比较两组临床疗效、肝纤维化指标[血清透明质酸(HA)、层粘连蛋白(LN)、Ⅲ型前胶原肽(PCⅢ)、Ⅳ型胶原(Ⅳ-C)]、肝功能[丙氨酸转氨酶(ALT)、血清白蛋白(ALB)、总胆红素(TBil)水平变化和乙肝病毒的脱氧核糖核酸(HBV-DNA)转阴率]、肝脏瞬时弹性硬度检查(FibroScan)肝脏弹性值。结果观察组治疗有效率为90.0%,高于对照组的70.0%,差异有统计学意义(P<0.05);观察组患者HA、LN、PCⅢ、Ⅳ-C水平明显低于对照组,差异有统计学意义(P<0.05);观察组患者ALT、TBil水平低于对照组,ALB水平高于对照组,差异有统计学意义(P<0.05);观察组和对照组HBV-DNA转阴率比较,差异无统计学意义(P>0.05);治疗后,观察组患者FiBroScan肝脏弹性值明显小于对照组,差异有统计学意义(P<0.05)。结论基于抗病毒治疗采用安络化纤丸联合水飞蓟治疗乙肝肝硬化临床疗效显著,可有效改善患者症状,在保护肝脏的同时,降低肝脏纤维化程度,改善肝硬化情况,防止病情继续发展。Objective To explore the clinical efficacy of Anluo Huaxian Pills combined with silybum marianum in the treatment of hepatitis B cirrhosis.Methods A total of 80 patients with hepatitis B cirrhosis who were admitted to the Sixth People's Hospital of Shenyang from June 2018 to November 2019 were selected as the research objects and were assigned into an observation group and a control group by random number table method,with 40 cases in each group.The control group was treated with antiviral therapy combined with liver protection,and the observation group was treated with Anluo Huaxian Pills plus antiviral therapy combined with liver protection.The clinical efficacy,liver fibrosis indicators[serum hyaluronic acid(HA),laminin(LN),typeⅢprocollagen peptide(PCⅢ),typeⅣcollagen(Ⅳ-C)],liver function[alanine]Acid aminotransferase(ALT),serum albumin(ALB),total bilirubin(TBil)level changes and hepatitis B virus deoxyribonucleic acid(HBV-DNA)conversion rate,liver elasticity value by transient liver elasticity test(FibroScan)were compared.Results The clinical efficacy rate in the observation group was 90.0%,which was higher than that of the control group of 70%,and the difference was statistically significant(P<0.05);the levels of HA,LN,PCⅢandⅣ-C in the observation group were significantly lower than those in the control group,and the difference was statistically significant(P<0.05);the ALT and TBil levels of the observation group were lower than the control group,and the ALB level was higher than the control group,the difference was statistically significant(P<0.05);the observation group and the control group had no statistically significant difference in the HBV-DNA conversion rate(P>0.05);after treatment,the FiBroScan liver elasticity of the observation group was significantly lower than that of the control group,and the difference was statistically significant(P<0.05).Conclusion Based on antiviral therapy,Anluo Huaxian Pills combined with Silybum marianum have significant clinical efficacy in the treatment of h

关 键 词：安络化纤丸 乙肝肝硬化 保肝治疗 抗病毒治疗 中医治疗 

分 类 号：R575.2[医药卫生—消化系统] R975[医药卫生—内科学]