垂体腺瘤组织lncRNA-POU3F3表达水平与术后复发的关系  

Relationship between expression level of lncRNA-POU3F3 in pituitary adenoma tissues and postoperative recurrence of patients with pituitary adenoma

作　　者：曾坚锋 李钢[1] 刘仲海[1] 王辉[1] ZENG Jian-feng;LI Gang;LIU Zhong-hai;WANG Hui(Department of Neurosurgery,Sanya Central Hospital(Hainan Thied People's Hospital),Sanya 572000,China)

机构地区：[1]三亚市中心医院(海南省第三人民医院)神经外科,海南572000

出　　处：《中国临床神经外科杂志》2021年第3期168-169,172,共3页Chinese Journal of Clinical Neurosurgery

基　　金：三亚市医疗卫生科技创新项目(2014YW40)。

摘　　要：目的探讨垂体腺瘤组织长链非编码核糖核酸(lncRNA)POU3F3的表达水平与术后复发的关系。方法收集2016年10月至2019年10月手术切除的垂体腺瘤组织110例,另选取同期颅脑损伤内减压术切除的正常脑组织40例为对照。实时荧光定量PCR检测lncRNA-POU3F3表达水平。垂体腺瘤病人术后随访1年。结果110例中,术后1年复发16例,复发率为14.55%;94例无复发。垂体腺瘤组织lncRNA-POU3F3表达水平(2.80±0.87)明显高于对照组(1.08±0.23;P<0.05)。以lncRNA-POU3F3表达水平均值2.80为界,分为高表达与低表达,110例中,高表达69例,低表达41例;高表达组复发率(20.29%,14/69)明显高于低表达组(4.88%,2/41;P<0.05)。多因素logistic回归分析显示,lncRNA-POU3F3高表达(OR=3.104,95%CI 1.096~8.791)是垂体腺瘤术后复发的独立危险因素(P<0.05)。结论垂体腺瘤组织lncRNA-POU3F3呈高表达,与术后复发密切相关。Objective To explore the expression change of lncRNA-POU3F3 in pituitary adenoma(PA)tissues and its relationship with the postoperative recurrence of patients with PA.Methods The exprsssion levels of lncRNA-POU3F3 were detected in PA tissues obtained from 110 patients with PA who underwent surgery from october 2016 to october 2019,and in normal cerenral tissues obtained from 40 patients with traumatic brain injury who underwent decompression using real-time fluorescence quantitative PCR.All the PA patients were followed up for 12 months.Results Of 110 PA patients,16 had recurrence 1 year after the operation,with a recurrence rate of 14.55%,and 94 did not recur.The expression level of lncRNA-POU3F3 in PA tissues(2.80±0.87)was significantly higher than that(1.08±0.23)in normal cerebral tissues(P<0.05).According to the mean level of lncRNA-POU3F3(2.80),69 PA patients had high expression of lncRNA-POU3F3 and 41 low expression.The recurrence rate of high expression group(20.29%,14/69)was significantly higher than that(4.88%,2/4)of the low expression group(P<0.05).Multivariate logistic regression analysis showed that high expression of lncRNA-POU3F3 was an independent risk factor for the postoperative recurrence of the PA patients(P<0.05).Conclusion Most of the human PA are of high expression of lncRNA-POU3F3,whivh is closely related to the postoperative recurrence of the patients with PA.

关 键 词：垂体腺瘤 lncRNA-POU3F3 术后复发 

分 类 号：R739.41[医药卫生—肿瘤] Q786[医药卫生—临床医学]