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作 者:莫晗 杨祎 张学龙[1,2] Mo Han;Yang Yi;Zhang Xuelong(Laboratory of Medical Genetics,Harbin Medical University,Harbin 150081,China;Key laboratory of preservation of human genetic resources and disease control in China(Harbin Medical University),Ministry of Education,Harbin 150081,China)
机构地区:[1]哈尔滨医科大学医学遗传学研究室,150081 [2]中国遗传资源保护与疾病防控教育部重点实验室(哈尔滨医科大学),150081
出 处:《国际遗传学杂志》2020年第6期353-360,共8页International Journal of Genetics
基 金:国家自然科学基金(81373220)。
摘 要:微小RNA(microRNA,miRNA)是基因表达的关键调节因子。而长链非编码RNA(long non-coding RNA,lncRNA)作为内源竞争RNA(competing endogenous RNA,ceRNA),与mRNA竞争结合miRNA。miRNA靶标种子区域或者lncRNA上与miRNA结合区域的单核苷酸多态(single nucleotide polymorphism,SNP)的存在,可能影响miRNA与mRNA以及lncRNA与miRNA的结合,从而影响靶基因的表达水平和肿瘤的形成。随着lncRNA和miRNA相关SNPs被不断发现,后续的功能分析及其与人类疾病的关系等研究内容不断进展,对大量数据进行整合和分析并对相关SNPs进行分类就显得尤为重要,由此诞生了众多的SNPs数据库。本文将从基本注释信息内容,相关功能分析和简单应用等方面回顾常用的lncRNA和miRNA相关的SNPs数据库,为研究人员提供参考。MicroRNA(miRNA)is a key regulator of gene expression.The long non-coding RNA(lncRNA),as a competing endogenous RNA(ceRNA),competes with mRNA to bind miRNA.The presence of single nucleotide polymorphisms(SNPs)in the miRNA target seed region or the miRNA binding region on lncRNA may affect the binding of miRNA to mRNA or lncRNA to miRNA,thereby affecting the expression level of target genes and tumor formation.With the continuous discovery of lncRNA and miRNA-related SNPs,subsequent functional analysis,its relationship with human diseases and the continuous development of other research contents,it is particularly important to integrate and analyze a large amount of data and classify related SNPs,which led to the birth of Numerous SNPs database.This article reviews the commonly used lncRNA and miRNA-related SNPs databases in terms of basic annotation information content,related functional analysis and simple applications,and provides references for researchers.
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