光声成像在皮肤肿瘤中的应用进展  

Application of photoacoustic imaging in the diagnosis and treatment of skin tumors

作　　者：周楚[1] 文龙 王佩茹 王秀丽[1,2] Zhou Chu;Wen Long;Wang Peiru;Wang Xiuli(Shanghai Skin Disease Clinical College of Anhui Medical University,Shanghai 200443,China;Institute of Photomedicine,Shanghai Skin Disease Hospital,Tongji University School of Medicine,Shanghai 200443,China)

机构地区：[1]安徽医科大学上海皮肤病临床学院,上海200443 [2]同济大学医学院光医学研究所上海市皮肤病医院,200443

出　　处：《中华皮肤科杂志》2021年第3期256-259,共4页Chinese Journal of Dermatology

基　　金：国家重点研发计划课题(2017YFC0111405);上海市科委科研计划项目(17411952500)。

摘　　要：光声成像技术利用“光进声出”的原理对肿瘤组织光学吸收体进行非侵入性成像,结合了光学成像高对比度和声学成像高穿透性的优点,无创且无电离辐射。但目前光声成像研究仍局限于实验室,该技术可用于皮肤原位黑素瘤及非黑素瘤性皮肤癌的检测及前哨淋巴结成像,并实现黑素瘤循环肿瘤细胞的检测与实时激光消融治疗,联合外源性显影剂可实现多功能成像和治疗。本文对光声成像技术在皮肤肿瘤的临床前实验进行综述,以期早日促进临床应用的转化。Photoacoustic imaging is a kind of non-invasive technology without ionizing radiation that can be used to image optical absorbers in tumor tissues according to the principle of"light in and sound out".It has the advantages of high contrast of optical imaging as well as high penetrability of acoustic imaging.However,current researches on photoacoustic imaging are still limited in the laboratory.This technology can be used for detection of cutaneous melanoma in situ and non-melanoma skin cancer,sentinel lymph node imaging,detection and eradication of circulating tumor cells by combining real-time laser ablation technique,and versatile imaging and treatment with the aid of exogenous imaging agents.This review summarizes preclinical experiments about photoacoustic imaging technology in skin tumors,with a view to promoting its clinical application at an early date.

关 键 词：光声技术 皮肤肿瘤 临床前实验 

分 类 号：R739.5[医药卫生—肿瘤]