木犀草素制剂的研究进展  

Research progress on pharmaceutical preparation of luteolin

作　　者：姚薛超 宁洪鑫 黄欢 黄龙岳 王世博 李祎亮[2] 侯文彬 YAO Xue-chao;NING Hong-xin;HUANG Huan;HUANG Long-yue;WANG Shi-bo;LI Yi-liang;HOU Wen-bin(Tianjin University of Traditional Chinese Medicine,Tianjin 301617,China;Tianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine,Institute of Radiation Medicine,Peking Union Medical College&Chinese Academy of Medical Sciences,Tianjin 300192,China)

机构地区：[1]天津中医药大学,天津301617 [2]北京协和医学院中国医学科学院放射医学研究所,天津市放射医学与分子核医学重点实验室,天津300192

出　　处：《中草药》2021年第3期873-882,共10页Chinese Traditional and Herbal Drugs

基　　金：中国医学科学院医学与健康科技创新工程项目(2016-I2M-3-022,2017-I2M-3-019);中央高校基本科研业务费专项资金资助项目(3332020057)。

摘　　要：木犀草素是一种具有多种药理活性的黄酮类化合物,但因其水溶性差及生物利用度低等限制了其临床应用。微粒给药系统、固体分散体、包合物、磷脂复合物、水凝胶等制剂技术的应用可提高木犀草素的生物利用度,综述了木犀草素制剂的研究进展,并阐述了其在细胞和动物实验中的应用,旨在促进其制剂开发及临床应用。Luteolin is a flavonoid compound with a variety of pharmacological activities,but its clinical application is limited due to its poor water solubility and low bioavailability.The application of microparticle drug delivery system,solid dispersion,inclusion complex,phospholipid complex,aquogel,and other preparation technique can improve the bioavailability of luteolin.Research progress on pharmaceutical preparation of luteolin and their applications in cell and animal experiments are reviewed in this article,in order to promote its preparation development and clinical application.

关 键 词：木犀草素 制剂 溶解性 生物利用度 微粒给药系统 固体分散体 包合物 磷脂复合物 水凝胶 

分 类 号：R283.3[医药卫生—中药学]