Fourier-domain optical coherence tomography-guided phototherapeutic keratectomy for the treatment of anterior corneal scarring  

作　　者：Yu-Li Yang Qian Jian Bo Liu Ke Wang Yu-Juan Chen Lian Tan Mei-Jun Pu Yong Liu 

机构地区：[1]Southwest Hospital/Southwest Eye Hospital,Third Military Medical University(Anny Medical University),Chongqing 400038,China [2]Chongqing Aier Mega Eye Hospital,Aier Eye Hospital Group,Chongqing 400060,China

出　　处：《International Journal of Ophthalmology(English edition)》2020年第11期1720-1726,共7页国际眼科杂志（英文版）

基　　金：Supported by Grants from National Natural Science Foundation of China(No.81900830);National Key Research&Development Intensification Key Project(No.2016YFC1101103,No.2018YFA0107302);Basic Science and Frontier Technology Project in Chongqing Science and Technology Commission(No.cstc2016jcyjA0297).

摘　　要：AIM:To evaluate the safety,visual and anatomic outcomes of fourier-domain optical coherence tomography(FD-OCT)-guided excimer laser phototherapeutic keratectomy(PTK)combined with photorefractive keratectomy(PRK)surgery in treating anterior corneal scarring.METHODS:Clinical data of 23 eyes of 21 patients with anterior corneal scarring underwent FD-OCT-guided PTK and PRK from Dec.2014 to Jul.2016 were reviewed.Patients were assessed for preoperative and postoperative uncorrected visual acuity(UCVA),best spectacle-corrected visual acuity(BSCVA),contrast sensitivity(CS),FD-OCT,corneal topography and colour figures of anterior segments.RESULTS:The preoperative corneal pathologic conditions included viral keratitis(7 patients,7 eyes),band keratopathy(2 patients,4 eyes),corneal dystrophy(4 patients,4 eyes),traumatic corneal disease(2 patients,2 eyes)and corneal chemical injury(6 patients,6 eyes).Mean follow-up time was 10.65(range,3-19)mo.UCVA(in IogMAR)improved from a mean of 0.79(95%Cl,0.28­1.29)preoperatively to a mean of 0.45(95%Cl,0.29-0.62)postoperatively(P=0.021).BSCVA(in IogMAR)improved from 0.57(95%Cl,0.27-0.88)preoperatively to a mean of 0.28(95%Cl,0.15-0.41)postoperatively(P=0.001).Corneal topographic indices postoperatively showed significant improvement in corneal cylinder(P=0.009),the surface regularity index(P=0.007)and surface asymmetry index(P=0.00).Postoperative spherical equivalent averaged-0.53 diopters(-1.49 to 0.42).No complications were associated with the treatment.CONCLUSION:FD-OCT-guided PTK combined with PRK is safe and effective for the treatment of anterior corneal scarring by eliminating or reducing corneal opacities.

关 键 词：corneal scar phototherapeutic keratectomy fourier-domain optical coherence tomography corneal opacity corneal topographic indices 

分 类 号：R779.6[医药卫生—眼科]