上海社区中老年人群脂肪肝指数与微量白蛋白尿的相关性研究  

The association between fatty liver index and microalbuminuria in middle-aged and elderly population in Shanghai

作　　者：左广民 彭魁[1] 李勉[1] 徐敏[1] 毕宇芳[1] 宁光[1] ZUO Guangmin;PENG Kui;LI Mian;XU Min;BI Yufang;NING Guang(Shanghai Clinical Center for Endocrine and Metabolic Diseases/Shanghai Institute of Endocrine and Metabolic Diseases/Department of Endocrine and Metabolic Diseases,Ruijin Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200025,China)

机构地区：[1]国家代谢性疾病临床医学研究中心,上海市内分泌代谢病研究所,上海交通大学医学院附属瑞金医院内分泌代谢病科,上海200025

出　　处：《诊断学理论与实践》2020年第6期605-609,共5页Journal of Diagnostics Concepts & Practice

基　　金：上海卫生系统重要疾病联合攻关项目(2013ZYJB1002)。

摘　　要：目的:探讨脂肪肝指数(fatty liver index,FLI)与微量白蛋白尿间的相关性。方法:于2009年选取上海淞南地区40岁以上的居民4012人进行横断面调查,采用问卷调查、体格检查等收集相关资料,观察其微量白蛋白尿情况,并计算FLI,分析该人群中FLI与微量白蛋白尿间的相关性。结果:最终共有3415人纳入分析,结果提示,随着FLI的升高,不同FLI分组[低FLI组(FLI<30)、中FLI组(30≤FLI<60)和高FLI组(≥60)]中微量白蛋白尿患病率逐渐增加,3组的微量白蛋白尿患病率分别为6.86%、10.99%、15.28%(P<0.0001)。在校正年龄、性别、吸烟、饮酒、运动、高血压、糖尿病、总胆固醇后,与低FLI组相比,高FLI组人群的微量白蛋白尿患病风险增加了58%(OR=1.58,95%CI为1.17~2.15,P=0.0032)。在同样的校正因素下,FLI数值每增加10,微量白蛋白尿患病风险增加10%(OR=1.10,95%CI为1.04~1.15,P=0.0002)。结论:上海淞南地区40岁以上人群中,FLI升高与其微量白蛋白尿的患病风险增加相关。Objective:To investigate the association between fatty liver index(FLI)and prevalence of microalbuminuria.Methods:A cross-sectional survey of 4012 subjects aged 40 years or older in Songnan Community,Shanghai was conducted in 2009.Questionnaire and anthropometric measurements were collected,and microalbuminuria and the FLI were determined.The association between FLI and microalbuminuria was analyzed.Results:Among the 3415 subjects in the current analysis,the prevalence of microalbuminuria increased with increase of the FLI.The corresponding prevalence of microalbuminuria were 6.86%,10.99% and 15.28% in low FLI group(FLI<30),intermediate FLI group(30≤FLI<60)and the high FLI group(FLI≥60),respectively(P<0.0001).After adjustment for age,sex,smoking status,current drinking,physical activity,systolic blood pressure,diabetes and total cholesterol,the high FLI group was associated with 58% increased risk of microalbuminuria compared with the low FLI group(OR=1.58,95%CI 1.17-2.15,P=0.0032).In the same adjusting model,the risk in prevalence of microalbuminuria increased 10% for each 10 unit increase in FLI(OR=1.10,95%CI 1.04-1.15,P=0.0002).Conclusions:FLI increas is associated with increased risk of microalbuminuria in subjects aged 40 years or older in Songnan Community,Shanghai.

关 键 词：脂肪肝指数 微量白蛋白尿 代谢紊乱 

分 类 号：R575.5[医药卫生—消化系统]