叶酸联合单唾液酸四己糖神经节苷脂钠治疗急性脑梗死的疗效及对同型半胱氨酸的影响  

Efficacy of folic acid combined with monosialotetrahexose ganglioside sodium in the treatment of acute cerebral infarction and its influence on homocysteine

作　　者：李姝 程莉晶 李慧 庞春阳 LI Shu;CHENG Li-jing;LI Hui(Department of Neurology,Benxi Jinshan Hospital,Benxi 117000,China)

机构地区：[1]本溪市金山医院神经内科,117000 [2]大理大学第一附属医院神经内科,671000

出　　处：《中国现代药物应用》2021年第6期1-4,共4页Chinese Journal of Modern Drug Application

摘　　要：目的探讨叶酸联合单唾液酸四己糖神经节苷脂钠治疗急性脑梗死的疗效及对同型半胱氨酸的影响。方法60例急性脑梗死患者,随机分为实验组及对照组,各30例。两组患者入院后均给予以常规药物治疗,实验组给予叶酸联合单唾液酸四己糖神经节苷脂钠治疗,对照组给予单唾液酸四己糖神经节苷脂钠治疗。比较两组患者入院当日及治疗第15天美国国立卫生研究院卒中量表(NIHSS)评分和同型半胱氨酸水平,治疗后临床疗效,不良反应发生情况。结果入院当日,两组患者的NIHSS评分比较,差异无统计学意义(P>0.05);治疗第15天,两组患者的NIHSS评分均低于本组入院当日,且实验组明显低于对照组,差异均具有统计学意义(P<0.05)。入院当日,两组患者的同型半胱氨酸水平比较,差异无统计学意义(P>0.05);治疗第15天,两组患者的同型半胱氨酸水平均低于本组入院当日,且实验组明显低于对照组,差异均具有统计学意义(P<0.05)。实验组临床治疗有效率为86.7%,对照组治疗有效率为63.3%,实验组治疗有效率明显高于对照组,差异有统计学意义(P<0.05)。两组不良反应发生率比较差异无统计学意义(P>0.05)。结论叶酸联合单唾液酸四己糖神经节苷脂钠能明显改善急性脑梗死患者的神经功能缺损情况,降低同型半胱氨酸水平,安全有效。Objective To discuss the efficacy of folic acid combined with monosialotetrahexose ganglioside sodium in the treatment of acute cerebral infarction and its influence on homocysteine.Methods A total of 60 patients with acute cerebral infarction were randomly divided into experimental group and control group,with 30 cases in each group.Both groups received conventional drug therapy.The experimental group was treated with folic acid combined with monosialotetrahexose ganglioside sodium,and the control group was treated with monosialotetrahexose ganglioside sodium.The National Institutes of Health stroke scale(NIHSS)scores and homocysteine levels on the day of admission and the 15th day of treatment,clinical efficacy after treatment and occurrence of adverse reactions were compared between the two groups.Results On the day of admission,there was no statistically significant difference in NIHSS score between the two groups(P>0.05).On the 15th day of treatment,the NIHSS score of the two groups were all lower than those on the day of admission,and the experimental group was obviously lower than the control group.The difference was statistically significant(P<0.05).On the day of admission,there was no statistically significant difference in homocysteine levels between the two groups(P>0.05).On the 15th day of treatment,the homocysteine levels of the two groups were lower than those on the day of admission,and the experimental group was obviously lower than the control group.The difference was statistically significant(P<0.05).The effective rate of clinical treatment of the experimental group was 86.7%,which was 63.3%of the control group,and the experimental group was obviously higher than the control group.The difference was statistically significant(P<0.05).There was no statistically significant difference in incidence of adverse reactions between the two groups(P>0.05).Conclusion Folic acid combined with monosialotetrahexose ganglioside sodium can obviously improve the neurological deficits in patients with acute cereb

关 键 词：急性脑梗死 单唾液酸四己糖神经节苷脂钠 叶酸 同型半胱氨酸 

分 类 号：R743.33[医药卫生—神经病学与精神病学]