早期介入微弹簧圈栓塞治疗脑动脉瘤破裂的疗效及预后研究  

Efficacy and prognosis of early interventional microcoil embolization in the treatment of rupturedcerebral aneurysms

作　　者：杨春雨 张德辉 吴开帅 王海飞 孙拓夫 刘屹阳 YANG Chun-yu;ZHANG De-hui;WU Kai-shuai(Department of Interventional Vascular Surgery,Panjin Central Hospital,Panjin 124000,China)

机构地区：[1]辽宁省盘锦市中心医院介入血管外科,124000

出　　处：《中国现代药物应用》2021年第6期27-29,共3页Chinese Journal of Modern Drug Application

摘　　要：目的阐述在治疗脑动脉瘤破裂中早期介入微弹簧圈栓塞治疗手段的临床疗效和预后结果。方法接受手术治疗的50例脑动脉瘤破裂患者,根据非盲法分组原则分为常规组和实验组,每组25例。实验组在患者入院3 d内开始行介入微弹簧圈栓塞治疗,常规组在患者入院3 d后开始行介入微弹簧圈栓塞治疗。比较两组患者治疗后栓塞情况;并发症发生情况;术后6个月的改良Rankin量表(mRS)、改良Barthel指数评定量表(MBI)评分;临床预后效果。结果实验组患者治疗后栓塞情况优于常规组,并发症发生率8.00%低于常规组的44.00%,差异具有统计学意义(P<0.05)。术后6个月,实验组患者mRS评分(1.1±0.2)分低于常规组的(2.5±0.4)分,MBI评分(96.5±2.2)分高于常规组的(81.6±3.7)分,差异均具有统计学意义(P<0.05)。实验组患者恢复自主呼吸时间(14.1±3.0)min、清醒时间(9.5±1.3)min、定向力恢复时间(12.5±3.5)min均短于常规组的(21.1±3.3)、(14.5±1.7)、(23.7±3.7)min,差异均具有统计学意义(t=7.847、11.681、10.995,P<0.05)。结论脑动脉瘤破裂患者早期接受介入微弹簧圈栓塞治疗,不仅能改善患者的预后指标,同时也可控制并发症的发生,其临床应用效果甚佳。Objective To discuss the clinical efficacy and prognosis of early interventional microcoil embolization in the treatment of ruptured cerebral aneurysms.Methods A total of 50 patients with ruptured cerebral aneurysms were divided into conventional group and experimental group according to non-blind method,with 25 cases in each group.The experimental group started the interventional microcoil embolization treatment within 3 d after admission,and the conventional group started the interventional microcoil embolization treatment 3 d after admission.The embolism after treatment,occurrence of complications,modified Rankin scale(mRS)and the modified Barthel index(MBI)score at 6 months after the operation and clinical prognostic effect was compared between the two groups.Results After treatment,the embolism status of the experimental group was better than that of conventional group,and incidence of complications 8.00%was lower than 44.00%of conventional group,and the difference was statistically significant(P<0.05).At 6 months after operation,the mRS score(1.1±0.2)points of the experimental group was lower than(2.5±0.4)points of conventional group,and MBI score(96.5±2.2)points was higher than(81.6±3.7)points of conventional group.All the difference was statistically significant(P<0.05).The recovery time of spontaneous breathing(14.1±3.0)min,wake-up time(9.5±1.3)min and orientation recovery time(12.5±3.5)min of the experimental group was shorter than(21.1±3.3),(14.5±1.7)and(23.7±3.7)min of conventional group,and the difference was statistically significant(t=7.847,11.681,10.995;P<0.05).Conclusion Early interventional embolization can not only improve the stability of prognosis indexes,but also control the occurrence of complications in patients with ruptured cerebral aneurysms.

关 键 词：脑动脉瘤 微弹簧圈栓塞 早期介入 疗效 预后 

分 类 号：R743[医药卫生—神经病学与精神病学]