芹菜素微粉的反溶剂制备工艺优化  

Optimization of Anti-solvent Preparing Technology of Apigenin Micro Mist

作　　者：李影[1] 王慧梅[1] 李琳[1] 王微[1] Li Ying;Wang Huimei;Li Lin;Wang Wei(College of Chemical Engineering and Resource Utilization,Northeast Forestry University,Harbin 150040,China)

机构地区：[1]东北林业大学化学化工与资源利用学院,哈尔滨150040

出　　处：《黑龙江科学》2021年第6期26-28,共3页Heilongjiang Science

基　　金：中央高校基本科研业务费专项资金项目(2572017EA03);国家重点研发计划课题(2016YFD0600805);哈尔滨医科大学心肌缺血重点实验室项目(KF201513)。

摘　　要：以二甲基甲酰胺(DMF)为溶剂、去离子水为反溶剂,制备芹菜素微粉,采用单因素分析法和响应面设计法优化制备工艺。研究结果表明:泊洛沙姆188浓度4 mg/mL、芹菜素浓度20 mg/mL、体积比15、搅拌速度1600 r/min、反应温度25℃,随着药物浓度、体积比、搅拌速度的增加,MPS呈现先减小后增大的趋势。Through taking DMF as solvent and deionized water as anti-solvent to prepare apigenin micro mist,the research adopts single factor analysis method and response surface design method to optimize preparation technology.The research results show that poloxamer 188 concentration is 4 mg/mL,apigenin concentration is 20 mg/mL,volume ratio is 15,stirring rate is 1600 r/min,and reaction temperature is 25℃.With the increase of drug concentration,volume ratio and stirring rate,MPS appears the trend decrease first and then increase.

关 键 词：芹菜素 反溶剂 单因素分析 响应面设计 

分 类 号：R944[医药卫生—药剂学]