In situ sol-gel synthesis of hyaluronan derivatives bio-nanocomposite hydrogels  

作　　者：U.D’Amora A.Ronca M.G.Raucci S.M.Dozio H.Lin Y.Fan X.Zhang L.Ambrosio 

机构地区：[1]Institute of Polymers,Composites and Biomaterials,National Research Council,Naples,Italy [2]Institute of Science and Technology for Ceramics,National Research Council,Faenza,Italy [3]School of Advanced Study“G.D’Annunzio”,University of Chieti-Pescara,Chieti Italy [4]National Engineering Research Center for Biomaterials,Sichuan University,Chengdu,China

出　　处：《Regenerative Biomaterials》2019年第5期249-258,共10页再生生物材料（英文版）

基　　金：the H2020-MSCA-RISE-2016,SECOND.R.I.,Grant Agreement No 734391;Progetto Premiale di AREA SCIENCE PARK“OPEN LAB-A System of Open Research Facilities”for the support。

摘　　要：The main driving idea of the present study was the comparison between two different chemical modifications of hyaluronic acid(HA)followed by the development of nanocomposite hydrogels directly in situ by biomineralization of photocrosslinkable HA polymers through sol-gel synthesis.In this way,it has been possible to overcome some limitations due to classical approaches based on the physical blending of inorganic fillers into polymer matrix.To this aim,methacrylated and maleated HA,synthesized with similar degree of substitution(DS)were compared in terms of mechanical and physico-chemical properties.The success of in situ biomineralization was highlighted by reflect Fourier transform infrared spectroscopy and thermogravimetric analysis.Furthermore,mechanical characterization demonstrated the reinforcing effect of inorganic fillers evidencing a strong correlation with DS.The swelling behavior resulted to be correlated with filler concentration.Finally,the cytotoxicity tests revealed the absence of toxic components and an increase of cell proliferation over culture time was observed,highlighting these bio-nanocomposite hyaluronan derivatives as biocompatible hydrogel with tunable properties.

关 键 词：hyaluronic acid derivatives PHOTOCROSSLINKING SOL-GEL NANOCOMPOSITES 

分 类 号：O63[理学—高分子化学]