Association of non-alcoholic fatty liver disease with gallstone disease in the United States hospitalized patient population  

作　　者：Asim Kichloo Shantanu Solanki Khwaja F Haq Dushyant Dahiya Beth Bailey Dhanshree Solanki Jagmeet Singh Michael Albosta Farah Wani Michael Aljadah Harshil Shah Hafiz Khan Syed-Mohammed Jafri 

机构地区：[1]Department of Internal Medicine,Central Michigan University College of Medicine,Saginaw,MI 48602,United States [2]Department of Internal Medicine,Guthrie Robert Packer Hospital,Sayre,PA 18840,United States [3]Department of Gastroenterology,Henry Ford Hospital,Detroit,MI 48202,United States [4]Health Administration,Rutgers University,New Brunswick,NJ 08901,United States [5]Department of Nephrology,Guthrie Robert Packer Hospital,Sayre,PA 18840,United States [6]Family Medicine,Samaritan Medical Center,Watertown,NY 13601,United States [7]Department of Internal Medicine,Medical College of Wisconsin,Milwaukee,WI 53226,United States [8]Department of Gastroenterology,Guthrie Robert Packer Hospital,Sayre,PA 18840,United States

出　　处：《World Journal of Gastrointestinal Pathophysiology》2021年第2期14-24,共11页世界胃肠病理生理学杂志（英文版）（电子版）

摘　　要：BACKGROUND Gallstones and cholecystectomy have been proposed as risk factors for nonalcoholic fatty liver disease(NAFLD).The reason for this may be that both gallstones,as well as NAFLD share several risk factors with regards to their development.Currently,there is a lack of sufficient evidence showing an association between these clinical conditions.AIM To determine whether there is a meaningful association between gallstones and cholecystectomy with NAFLD.METHODS We queried the National Inpatient Sample database from the years 2016 and 2017 using International Classification of Diseases,10th revision,Clinical Modification diagnosis codes to identify hospitalizations with a diagnosis of gallstone disease(GSD)(includes calculus of gallbladder without cholecystitis without obstruction and acquired absence of gallbladder)as well as NAFLD(includes simple fatty liver and non-alcoholic steatohepatitis).Odds ratios(ORs)measuring the association between GSD(includes gallstones and cholecystectomy)and NAFLD were calculated using logistic regression after adjusting for confounding variables.RESULTS Out of 14294784 hospitalizations in 2016-2017,159259 were found to have NAFLD.The prevalence of NAFLD was 3.3%in patients with GSD and 1%in those without.NAFLD was prevalent in 64.3%of women with GSD as compared to 35.7%of men with GSD.After controlling for various confounders associated with NAFLD and GSD,multivariate-adjusted analysis showed that there was an association between NAFLD with gallstones[OR=6.32;95%confidence interval(CI):6.15-6.48]as well as cholecystectomy(OR=1.97;95%CI:1.93-2.01).The association between NAFLD and gallstones was stronger in men(OR=6.67;95%CI:6.42-6.93)than women(OR=6.05;95%CI:5.83-6.27).The association between NAFLD and cholecystectomy was stronger in women(OR=2.01;95%CI:1.96-2.06)than men(OR=1.85;95%CI:1.79-1.92).P value was less than 0.001 for all comparisons.CONCLUSION NAFLD is more prevalent in women with GSD than men.The association between NAFLD and cholecystectomy/gallstones indicates th

关 键 词：GALLSTONES Non-alcoholic fatty liver disease GASTROENTEROLOGY HEPATOLOGY Non-alcoholic steatohepatitis CHOLECYSTECTOMY 

分 类 号：R575.5[医药卫生—消化系统] R575.62[医药卫生—内科学]